Lpg0393 of Legionella pneumophila is a guanine-nucleotide exchange factor for Rab5, Rab21 and Rab22

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dc.contributor.authorY S Sohn-
dc.contributor.authorHo Chul Shin-
dc.contributor.authorW S Park-
dc.contributor.authorJ Ge-
dc.contributor.authorC H Kim-
dc.contributor.authorB L Lee-
dc.contributor.authorW D Heo-
dc.contributor.authorJ U Jung-
dc.contributor.authorD J Rigden-
dc.contributor.authorB H Oh-
dc.date.accessioned2017-04-19T10:04:21Z-
dc.date.available2017-04-19T10:04:21Z-
dc.date.issued2015-
dc.identifier.issn1932-6203-
dc.identifier.uri10.1371/journal.pone.0118683ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/12595-
dc.description.abstractLegionella pneumophila, a human intracellular pathogen, encodes about 290 effector proteins that are translocated into host cells through a secretion machinery. Some of these proteins have been shown to manipulate or subvert cellular processes during infection, but functional roles of a majority of them remain unknown. Lpg0393 is a newly identified Legionella effector classified as a hypothetical protein. Through X-ray crystallographic analysis, we show that Lpg0393 contains a Vps9-like domain, which is structurally most similar to the catalytic core of human Rabex-5 that activates the endosomal Rab proteins Rab5, Rab21 and Rab22. Consistently, Lpg0393 exhibited a guanine-nucleotide exchange factor activity toward the endosomal Rabs. This work identifies the first example of a bacterial guanine-nucleotide exchange factor that is active towards the Rab5 sub-cluster members, implying that the activation of these Rab proteins might be advantageous for the intracellular survival of Legionella.-
dc.publisherPublic Library of Science-
dc.titleLpg0393 of Legionella pneumophila is a guanine-nucleotide exchange factor for Rab5, Rab21 and Rab22-
dc.title.alternativeLpg0393 of Legionella pneumophila is a guanine-nucleotide exchange factor for Rab5, Rab21 and Rab22-
dc.typeArticle-
dc.citation.titlePLoS One-
dc.citation.number3-
dc.citation.endPagee0118683-
dc.citation.startPagee0118683-
dc.citation.volume10-
dc.contributor.affiliatedAuthorHo Chul Shin-
dc.contributor.alternativeName손영식-
dc.contributor.alternativeName신호철-
dc.contributor.alternativeName박위선-
dc.contributor.alternativeNameGe-
dc.contributor.alternativeName김찬희-
dc.contributor.alternativeName이복렬-
dc.contributor.alternativeName허원도-
dc.contributor.alternativeName정재-
dc.contributor.alternativeNameRigden-
dc.contributor.alternativeName오병하-
dc.identifier.bibliographicCitationPLoS One, vol. 10, no. 3, pp. e0118683-e0118683-
dc.identifier.doi10.1371/journal.pone.0118683-
dc.description.journalClassY-
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