Effect of Clitocybin A on the proliferation of dermal papilla cells = Clitocybin A의 모유두 세포증식 효능

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Effect of Clitocybin A on the proliferation of dermal papilla cells = Clitocybin A의 모유두 세포증식 효능
J I Kang; M K Kim; E S Yoo; Ick-Dong Yoo; H K Kang
Bibliographic Citation
Korean Journal of Pharmacognosy, vol. 45, no. 4, pp. 288-293
Publication Year
The present study was conducted to evaluate the hair growth-promoting effect of Clitocybin A from mushroom Clitocybe aurantiaca with dermal papilla cells (DPCs), which play important roles in the regulation of hair cycle. Clitocybin A significantly increased the proliferation of immortalized rat vibrissa DPCs. Flow cytometry analysis revealed that Clitocybin A promoted cell-cycle progression through G0/G1 to S phase in immortalized rat vibrissa DPCs. In addition, Clitocybin A increased the level of cell cycle proteins such as cyclin D1, phospho-pRB, and phospho-CDK2. To elucidate the molecular mechanisms of Clitocybin A on the proliferation of DPCs, we examined the activation of wnt/β-catenin signaling which is known to regulate hair follicle development, differentiation and hair growth. Clitocybin A activated wnt/β-catenin signaling via the increase of phospho(ser552)-β-catenin, phospho(ser675)-β-catenin and phospho(ser9)-GSK3β. Furthermore, Clitocybin A markedly increased the activation of extracellular signal-regulated kinase (ERK). These results suggest that the Clitocybin A may induce hair growth by proliferation of DPCs via cell-cycle progression as well as the activation of Wnt/β-catenin signaling and ERK pathway.
Cell cycleDermal papilla cellsERKHair growthRAFWnt/β-catenin
Korea Soc-Assoc-Inst
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