Exploring the genetic signature of body size in Yucatan miniature pig

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Exploring the genetic signature of body size in Yucatan miniature pig
H Kim; K D Song; H J Kim; W Park; J Kim; T Lee; D H Shin; W Kwak; Y J Kwon; S Sung; S Moon; K T Lee; Namshin Kim; J K Hong; K Y Eo; K S Seo; G Kim; S Park; C H Yun; H Kim; K Choi; J Kim; W K Lee; D K Kim; J D Oh; E S Kim; S Cho; H K Lee; T H Kim; H Kim
Bibliographic Citation
PLoS One, vol. 10, no. 4, pp. e0121732-e0121732
Publication Year
Since being domesticated about 10,000-12,000 years ago, domestic pigs (Sus scrofa domesticus ) have been selected for traits of economic importance, in particular large body size. However, Yucatan miniature pigs have been selected for small body size to withstand high temperature environment and for laboratory use. This renders the Yucatan miniature pig a valuable model for understanding the evolution of body size. We investigate the genetic signature for selection of body size in the Yucatan miniature pig. Phylogenetic distance of Yucatan miniature pig was compared to other large swine breeds (Yorkshire, Landrace, Duroc and wild boar). By estimating the XP-EHH statistic using re-sequencing data derived from 70 pigs, we were able to unravel the signatures of selection of body size. We found that both selections at the level of organism, and at the cellular level have occurred. Selection at the higher levels include feed intake, regulation of body weight and increase in mass while selection at the molecular level includes cell cycle and cell proliferation. Positively selected genes probed by XP-EHH may provide insight into the docile character and innate immunity as well as body size of Yucatan miniature pig.
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