Exploring the genetic signature of body size in Yucatan miniature pig

Cited 18 time in scopus
Metadata Downloads
Title
Exploring the genetic signature of body size in Yucatan miniature pig
Author(s)
H Kim; K D Song; H J Kim; W Park; J Kim; T Lee; D H Shin; W Kwak; Y J Kwon; S Sung; S Moon; K T Lee; Namshin Kim; J K Hong; K Y Eo; K S Seo; G Kim; S Park; C H Yun; H Kim; K Choi; J Kim; W K Lee; D K Kim; J D Oh; E S Kim; S Cho; H K Lee; T H Kim; H Kim
Bibliographic Citation
PLoS One, vol. 10, no. 4, pp. e0121732-e0121732
Publication Year
2015
Abstract
Since being domesticated about 10,000-12,000 years ago, domestic pigs (Sus scrofa domesticus ) have been selected for traits of economic importance, in particular large body size. However, Yucatan miniature pigs have been selected for small body size to withstand high temperature environment and for laboratory use. This renders the Yucatan miniature pig a valuable model for understanding the evolution of body size. We investigate the genetic signature for selection of body size in the Yucatan miniature pig. Phylogenetic distance of Yucatan miniature pig was compared to other large swine breeds (Yorkshire, Landrace, Duroc and wild boar). By estimating the XP-EHH statistic using re-sequencing data derived from 70 pigs, we were able to unravel the signatures of selection of body size. We found that both selections at the level of organism, and at the cellular level have occurred. Selection at the higher levels include feed intake, regulation of body weight and increase in mass while selection at the molecular level includes cell cycle and cell proliferation. Positively selected genes probed by XP-EHH may provide insight into the docile character and innate immunity as well as body size of Yucatan miniature pig.
ISSN
1932-6203
Publisher
Public Library of Science
DOI
http://dx.doi.org/10.1371/journal.pone.0121732
Type
Article
Appears in Collections:
Division of Biomedical Research > Genome Editing Research Center > 1. Journal Articles
Files in This Item:

Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.