Complestatin exerts antibacterial activity by the inhibition of fatty acid synthesis

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dc.contributor.authorYun Ju Kwon-
dc.contributor.authorHyun Ju Kim-
dc.contributor.authorWon Gon Kim-
dc.date.accessioned2017-04-19T10:05:33Z-
dc.date.available2017-04-19T10:05:33Z-
dc.date.issued2015-
dc.identifier.issn0918-6158-
dc.identifier.uri10.1248/bpb.b14-00824.ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/12620-
dc.description.abstractBacterial enoyl-acyl carrier protein (ACP) reductase has been confirmed as a novel target for antibacterial drug development. In the screening of inhibitors of Staphylococcus aureus enoyl-ACP reductase (FabI), complestatin was isolated as a potent inhibitor of S. aureus FabI together with neuroprotectin A and chloropeptin I from Streptomyces chartreusis AN1542. Complestatin and related compounds inhibited S. aureus FabI with IC50 of 0.3-0.6 μM. They also prevented the growth of S. aureus as well as methicillin-resistance S. aureus (MRSA) and quinolone-resistant S. aureus (QRSA), with minimum inhibitory concentrations (MICs) of 2-4 μg/mL. Consistent with its FabI-inhibition, complestatin selectively inhibited the intracellular fatty acid synthesis in S. aureus, whereas it did not affect the macromolecular biosynthesis of other cellular components, such as DNA, RNA, proteins, and the cell wall. Additionally, supplementation with exogenous fatty acids reversed the antibacterial effect of complestatin, demonstrating that it targets fatty acid synthesis. In this study, we reported that complestatin and related compounds showed potent antibacterial activity via inhibiting fatty acid synthesis.-
dc.publisherPharmaceutical Soc Japan-
dc.titleComplestatin exerts antibacterial activity by the inhibition of fatty acid synthesis-
dc.title.alternativeComplestatin exerts antibacterial activity by the inhibition of fatty acid synthesis-
dc.typeArticle-
dc.citation.titleBiological & Pharmaceutical Bulletin-
dc.citation.number5-
dc.citation.endPage721-
dc.citation.startPage715-
dc.citation.volume38-
dc.contributor.affiliatedAuthorYun Ju Kwon-
dc.contributor.affiliatedAuthorHyun Ju Kim-
dc.contributor.affiliatedAuthorWon Gon Kim-
dc.contributor.alternativeName권윤주-
dc.contributor.alternativeName김현주-
dc.contributor.alternativeName김원곤-
dc.identifier.bibliographicCitationBiological & Pharmaceutical Bulletin, vol. 38, no. 5, pp. 715-721-
dc.identifier.doi10.1248/bpb.b14-00824-
dc.subject.keywordAntibacterial-
dc.subject.keywordComplestatin-
dc.subject.keywordEnoyl-acyl carrier protein reductase-
dc.subject.keywordFatty acid synthesis-
dc.subject.keywordStaphylococcus aureus-
dc.subject.localAntibacterials-
dc.subject.localantibacterials-
dc.subject.localantibacterial-
dc.subject.localAntibacterial-
dc.subject.localcomplestatin-
dc.subject.localComplestatin-
dc.subject.localEnoyl-acyl carrier protein reductase-
dc.subject.localfatty acid synthesis-
dc.subject.localFatty acid synthesis-
dc.subject.localStaphylococcus aureus-
dc.subject.localstaphylococcus aureus-
dc.description.journalClassY-
Appears in Collections:
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
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