Discovery of a novel series of indolyl hydrazide derivatives as diacylglycerol acyltransferase-1 inhibitors
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | M Kim | - |
| dc.contributor.author | J Kwon | - |
| dc.contributor.author | Mun-Ock Kim | - |
| dc.contributor.author | S Singh | - |
| dc.contributor.author | S K Kim | - |
| dc.contributor.author | K Lee | - |
| dc.contributor.author | K Lee | - |
| dc.contributor.author | Hyun Sun Lee | - |
| dc.contributor.author | Y Choi | - |
| dc.date.accessioned | 2017-04-19T10:05:50Z | - |
| dc.date.available | 2017-04-19T10:05:50Z | - |
| dc.date.issued | 2015 | - |
| dc.identifier.issn | 0253-2964 | - |
| dc.identifier.uri | 10.1002/bkcs.10123 | ko |
| dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/12629 | - |
| dc.description.abstract | A novel series of hydrazide derivatives were synthesized as potential diacylglycerol acyltransferase (DGAT) inhibitors. Among them, compounds 8u and 8v exhibited selective and potent DGAT-1 inhibitory activities. In addition, compound 8u dose-dependently inhibited triglyceride synthesis in HepG2 cell lines. Furthermore, treatment with compound 8u for an oral lipid tolerance test showed a significant decrease in plasma triglyceride levels compared with vehicle-treated control animals, indicating delayed absorption of triglyceride after an acute lipid challenge. | - |
| dc.publisher | Wiley | - |
| dc.title | Discovery of a novel series of indolyl hydrazide derivatives as diacylglycerol acyltransferase-1 inhibitors | - |
| dc.title.alternative | Discovery of a novel series of indolyl hydrazide derivatives as diacylglycerol acyltransferase-1 inhibitors | - |
| dc.type | Article | - |
| dc.citation.title | Bulletin of Korean Chemical Society | - |
| dc.citation.number | 2 | - |
| dc.citation.endPage | 635 | - |
| dc.citation.startPage | 628 | - |
| dc.citation.volume | 36 | - |
| dc.contributor.affiliatedAuthor | Mun-Ock Kim | - |
| dc.contributor.affiliatedAuthor | Hyun Sun Lee | - |
| dc.contributor.alternativeName | 김민경 | - |
| dc.contributor.alternativeName | 권진선 | - |
| dc.contributor.alternativeName | 김문옥 | - |
| dc.contributor.alternativeName | Singh | - |
| dc.contributor.alternativeName | 김상겸 | - |
| dc.contributor.alternativeName | 이경 | - |
| dc.contributor.alternativeName | 이기호 | - |
| dc.contributor.alternativeName | 이현선 | - |
| dc.contributor.alternativeName | 최용석 | - |
| dc.identifier.bibliographicCitation | Bulletin of Korean Chemical Society, vol. 36, no. 2, pp. 628-635 | - |
| dc.identifier.doi | 10.1002/bkcs.10123 | - |
| dc.subject.keyword | Diacylglycerol O-acyltransferase | - |
| dc.subject.keyword | Diacylglycerol O-acyltransferase inhibitor | - |
| dc.subject.keyword | Hydrazide | - |
| dc.subject.keyword | Obesity | - |
| dc.subject.keyword | Triglyceride | - |
| dc.subject.local | Diacylglycerol O-acyltransferase | - |
| dc.subject.local | Diacylglycerol O-acyltransferase inhibitor | - |
| dc.subject.local | Hydrazide | - |
| dc.subject.local | Obesity | - |
| dc.subject.local | obesity | - |
| dc.subject.local | triglyceride | - |
| dc.subject.local | Triglycerides | - |
| dc.subject.local | Triglyceride | - |
| dc.subject.local | triglyceride (TG) | - |
| dc.description.journalClass | Y | - |
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- Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
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