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- Title
- Convenient synthesis of novel phenylpyrimido[1,2-c]-thienopyrimidinones as IL-6/STAT3 inhibitors
- Author(s)
- J H Park; S Y Hong; J Kim; H J Lee; H H Lee; K Y Kim; Seung Woong Lee; Hyun-Mee Oh; Mun Chual Rho; B G Lee; Y H Song
- Bibliographic Citation
- Heterocycles, vol. 91, no. 4, pp. 835-848
- Publication Year
- 2015
- Abstract
- New phenylpyrimido[1,2-c]thienopyrimidinones 4A and 4B were easily prepared in good yields by the one-pot reaction of formamidine derivatives 2 of 4-aminothienopyrimidine 1 with phenylacetyl chlorides. The application of this convenient and reliable method could be used for the synthesis of a variety of pyrimido[1,2-c]thienopyrimidinone derivatives of biological importance. Some of the compounds synthesized showed strong IL-6/STAT3 inhibition.
- ISSN
- 0385-5414
- Publisher
- Elsevier
- DOI
- http://dx.doi.org/10.3987/COM-15-13166
- Type
- Article
- Appears in Collections:
- Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
- Files in This Item:
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