Convenient synthesis of novel phenylpyrimido[1,2-c]-thienopyrimidinones as IL-6/STAT3 inhibitors

Cited 5 time in scopus
Metadata Downloads
Title
Convenient synthesis of novel phenylpyrimido[1,2-c]-thienopyrimidinones as IL-6/STAT3 inhibitors
Author(s)
J H Park; S Y Hong; J Kim; H J Lee; H H Lee; K Y Kim; Seung Woong Lee; Hyun-Mee Oh; Mun Chual Rho; B G Lee; Y H Song
Bibliographic Citation
Heterocycles, vol. 91, no. 4, pp. 835-848
Publication Year
2015
Abstract
New phenylpyrimido[1,2-c]thienopyrimidinones 4A and 4B were easily prepared in good yields by the one-pot reaction of formamidine derivatives 2 of 4-aminothienopyrimidine 1 with phenylacetyl chlorides. The application of this convenient and reliable method could be used for the synthesis of a variety of pyrimido[1,2-c]thienopyrimidinone derivatives of biological importance. Some of the compounds synthesized showed strong IL-6/STAT3 inhibition.
ISSN
0385-5414
Publisher
Elsevier
DOI
http://dx.doi.org/10.3987/COM-15-13166
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.