Low density lipoprotein-oxidation inhibitory phytochemicals from the fruits of rhus parviflora

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Title
Low density lipoprotein-oxidation inhibitory phytochemicals from the fruits of rhus parviflora
Author(s)
S Shrestha; J H Park; J G Cho; D Y Lee; Ji Hyun Kang; Hua Li; Tae Sook Jeong; S K Cho; D S Lee; N I Baek
Bibliographic Citation
Journal of Applied Biological Chemistry, vol. 58, no. 2, pp. 109-112
Publication Year
2015
Abstract
Fruits of Rhus parviflora were extracted with 80% aqueous methanol (MeOH), and the concentrated extract was partitioned using ethyl acetate (EtOAc), n-butanol (n-BuOH), and H2O, successively. Purification of EtOAc fraction led to isolation of fifteen polyphenols of which structures were identified by spectroscopic methods including 2D-NMR. Most compounds apart from compound 10 inhibited low density lipoproteinoxidation within IC50 value of 10 μM. Among compounds, taxifolin (2), quercetin 3-O-α-L-rhamnopyranoside (13), agathisflavone (5) sulfuretin (4), and aureusidin (3) showed IC50 values 0.9, 0.8, 5.8, 2.9, and 2.4 μM which were of highly significant in comparison positive control butylated hydroxytoluene with IC50 value of 2.1 μM. The results indicate fruits of R. parviflora as a source of antihypercholesterolemic compounds.
Keyword
AnacardiaceaeAnti-hypercholesterolemicAuroneBiflavonoidLow density lipoprotein-oxidationRhus parviflora
ISSN
1229-2737
Publisher
Springer
DOI
http://dx.doi.org/10.3839/jabc.2015.019
Type
Article
Appears in Collections:
Division of Biomaterials Research > Industrial Bio-materials Research Center > 1. Journal Articles
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