Isolation and characterization of dammarane-type saponins from Gynostemma pentaphyllum and their inhibitory effects on IL-6-induced STAT3 activation

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dc.contributor.authorChul Lee-
dc.contributor.authorJ W Lee-
dc.contributor.authorQ Jin-
dc.contributor.authorH Jang-
dc.contributor.authorHyun Jae Jang-
dc.contributor.authorMun Chual Rho-
dc.contributor.authorM K Lee-
dc.contributor.authorC K Lee-
dc.contributor.authorM K Lee-
dc.contributor.authorB Y Hwang-
dc.date.accessioned2017-04-19T10:06:31Z-
dc.date.available2017-04-19T10:06:31Z-
dc.date.issued2015-
dc.identifier.issn01633864-
dc.identifier.uri10.1021/np500803eko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/12668-
dc.description.abstractFive new dammarane-type saponins, gypenosides GD1-GD5 (1-5), along with six known saponins (6-11), were isolated from the aerial parts of Gynostemma pentaphyllum using various chromatographic methods. Their structures were elucidated by a combination of spectroscopic and spectrometric data, including 1D and 2D NMR and HRESIMS. All isolates were tested for their inhibitory effects on IL-6-induced STAT3 promoter activity in Hep3B cells. Compounds 1, 9, and 11 displayed potent inhibitory effects, with IC50 values ranging from 0.27 to 0.59 μM.-
dc.publisherAmer Chem Soc-
dc.titleIsolation and characterization of dammarane-type saponins from Gynostemma pentaphyllum and their inhibitory effects on IL-6-induced STAT3 activation-
dc.title.alternativeIsolation and characterization of dammarane-type saponins from Gynostemma pentaphyllum and their inhibitory effects on IL-6-induced STAT3 activation-
dc.typeArticle-
dc.citation.titleJournal of Natural Products-
dc.citation.number5-
dc.citation.endPage976-
dc.citation.startPage971-
dc.citation.volume78-
dc.contributor.affiliatedAuthorHyun Jae Jang-
dc.contributor.affiliatedAuthorMun Chual Rho-
dc.contributor.alternativeName이철-
dc.contributor.alternativeName이진우-
dc.contributor.alternativeNameJin-
dc.contributor.alternativeName장하리-
dc.contributor.alternativeName장현재-
dc.contributor.alternativeName노문철-
dc.contributor.alternativeName이명구-
dc.contributor.alternativeName이종길-
dc.contributor.alternativeName이미경-
dc.contributor.alternativeName황방연-
dc.identifier.bibliographicCitationJournal of Natural Products, vol. 78, no. 5, pp. 971-976-
dc.identifier.doi10.1021/np500803e-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
Jeonbuk Branch Institute > Immunoregulatory materials Research Center > 1. Journal Articles
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