DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chul Lee | - |
dc.contributor.author | J W Lee | - |
dc.contributor.author | Q Jin | - |
dc.contributor.author | H Jang | - |
dc.contributor.author | Hyun Jae Jang | - |
dc.contributor.author | Mun Chual Rho | - |
dc.contributor.author | M K Lee | - |
dc.contributor.author | C K Lee | - |
dc.contributor.author | M K Lee | - |
dc.contributor.author | B Y Hwang | - |
dc.date.accessioned | 2017-04-19T10:06:31Z | - |
dc.date.available | 2017-04-19T10:06:31Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0163-3864 | - |
dc.identifier.uri | 10.1021/np500803e | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/12668 | - |
dc.description.abstract | Five new dammarane-type saponins, gypenosides GD1-GD5 (1-5), along with six known saponins (6-11), were isolated from the aerial parts of Gynostemma pentaphyllum using various chromatographic methods. Their structures were elucidated by a combination of spectroscopic and spectrometric data, including 1D and 2D NMR and HRESIMS. All isolates were tested for their inhibitory effects on IL-6-induced STAT3 promoter activity in Hep3B cells. Compounds 1, 9, and 11 displayed potent inhibitory effects, with IC50 values ranging from 0.27 to 0.59 μM. | - |
dc.publisher | Amer Chem Soc | - |
dc.title | Isolation and characterization of dammarane-type saponins from Gynostemma pentaphyllum and their inhibitory effects on IL-6-induced STAT3 activation | - |
dc.title.alternative | Isolation and characterization of dammarane-type saponins from Gynostemma pentaphyllum and their inhibitory effects on IL-6-induced STAT3 activation | - |
dc.type | Article | - |
dc.citation.title | Journal of Natural Products | - |
dc.citation.number | 5 | - |
dc.citation.endPage | 976 | - |
dc.citation.startPage | 971 | - |
dc.citation.volume | 78 | - |
dc.contributor.affiliatedAuthor | Chul Lee | - |
dc.contributor.affiliatedAuthor | Hyun Jae Jang | - |
dc.contributor.affiliatedAuthor | Mun Chual Rho | - |
dc.contributor.alternativeName | 이철 | - |
dc.contributor.alternativeName | 이진우 | - |
dc.contributor.alternativeName | Jin | - |
dc.contributor.alternativeName | 장하리 | - |
dc.contributor.alternativeName | 장현재 | - |
dc.contributor.alternativeName | 노문철 | - |
dc.contributor.alternativeName | 이명구 | - |
dc.contributor.alternativeName | 이종길 | - |
dc.contributor.alternativeName | 이미경 | - |
dc.contributor.alternativeName | 황방연 | - |
dc.identifier.bibliographicCitation | Journal of Natural Products, vol. 78, no. 5, pp. 971-976 | - |
dc.identifier.doi | 10.1021/np500803e | - |
dc.description.journalClass | Y | - |
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