MED30 regulates the proliferation and motility of gastric cancer cells

Cited 7 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorY J Lee-
dc.contributor.authorM E Han-
dc.contributor.authorS J Baek-
dc.contributor.authorSeon-Young Kim-
dc.contributor.authorS O Oh-
dc.date.accessioned2017-04-19T10:07:24Z-
dc.date.available2017-04-19T10:07:24Z-
dc.date.issued2015-
dc.identifier.issn19326203-
dc.identifier.uri10.1371/journal.pone.0130826ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/12687-
dc.description.abstractMED30 is an essential member of the mediator complex that forms a hub between transcriptional activators and RNA polymerase II. However, the expressions and roles of MED30 have been poorly characterized in cancer. In this study, we examined the functional roles of MED30 during gastric cancer progression. It was found that MED30 was overexpressed in gastric cancer tissues and cell lines. Moreover, MED30 overexpression increased the proliferation, migration, and invasion of gastric cancer cells, whereas MED30 knockdown inhibited these effects. Furthermore the knockdown significantly inhibited tumorigenicity in SCID mice. MED30 also promoted the expressions of genes related to epithelial-mesenchymal transition and induced a fibroblast-like morphology. This study shows MED30 has pathophysiological roles in the proliferation, migration, and invasion of gastric cancer cells and suggests that MED30 should be viewed as a potent therapeutic target for malignant gastric carcinoma-
dc.publisherPublic Library of Science-
dc.titleMED30 regulates the proliferation and motility of gastric cancer cells-
dc.title.alternativeMED30 regulates the proliferation and motility of gastric cancer cells-
dc.typeArticle-
dc.citation.titlePLoS One-
dc.citation.number6-
dc.citation.endPagee0130826-
dc.citation.startPagee0130826-
dc.citation.volume10-
dc.contributor.affiliatedAuthorSeon-Young Kim-
dc.contributor.alternativeName이용주-
dc.contributor.alternativeName한명은-
dc.contributor.alternativeName백수진-
dc.contributor.alternativeName김선영-
dc.contributor.alternativeName오새옥-
dc.identifier.bibliographicCitationPLoS One, vol. 10, no. 6, pp. e0130826-e0130826-
dc.identifier.doi10.1371/journal.pone.0130826-
dc.description.journalClassY-
Appears in Collections:
Korea Bioinformation Center > 1. Journal Articles
Files in This Item:

Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.