Effect of 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol on immune functions in healthy adults in a randomized controlled trial

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Title
Effect of 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol on immune functions in healthy adults in a randomized controlled trial
Author(s)
H J Hwang; K Y Sohn; Y H Han; S Chong; S Y Yoon; Young-Jun Kim; Jinseoun Jeong; S H Kim; Jae Wha Kim
Bibliographic Citation
Immune Network, vol. 15, no. 3, pp. 150-160
Publication Year
2015
Abstract
We previously reported that 1-palmitoyl-2-linoleoyl-3- acetyl-rac-glycerol (PLAG) accelerates hematopoiesis and has an improving effect on animal disease models such as sepsis and asthma. The effects of PLAG supplementation on immune modulation were assessed in healthy men and women. The objective was to evaluate the effects of PLAG supplementation on immune regulatory functions such as activities of immune cells and cytokine production. A randomized double blind placebo-controlled trial was conducted. Seventy-five participants were assigned to one of two groups; all participants had an appropriate number of white blood cells on the testing day. The PLAG group (n=27) received oral PLAG supplements and the control group (n=22) received oral soybean oil supplements. IL-4 and IL-6 production by peripheral blood mononuclear cells (PBMC) were lower (p<0.001 and p<0.001, respectively) with PLAG than with soybean oil. However, the production of IL-2 and IFN-γ by PBMC was unaltered with PLAG supplementation. The B cell proliferation decreased significantly in the PLAG group compared to the soybean oil control (p<0.05). The intake of PLAG in healthy adults for 4 weeks was deemed safe. These data suggest that PLAG has an immunomodulatory function that inhibits the excessive immune activity of immunological disorders such as atopic and autoimmune diseases. PLAG could improve the condition of these diseases safely as a health food supplement. [Immune
Keyword
HumanLipid supplementNutritionImmunomodulationPLAG (1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol)
ISSN
I000-0135
Publisher
South Korea
DOI
http://dx.doi.org/10.4110/in.2015.15.3.150
Type
Article
Appears in Collections:
Division of Biomaterials Research > Cell Factory Research Center > 1. Journal Articles
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