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- Title
- Effect of 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol on immune functions in healthy adults in a randomized controlled trial
- Author(s)
- H J Hwang; K Y Sohn; Y H Han; S Chong; S Y Yoon; Young-Jun Kim; Jinseoun Jeong; S H Kim; Jae Wha Kim
- Bibliographic Citation
- Immune Network, vol. 15, no. 3, pp. 150-160
- Publication Year
- 2015
- Abstract
- We previously reported that 1-palmitoyl-2-linoleoyl-3-
acetyl-rac-glycerol (PLAG) accelerates hematopoiesis and
has an improving effect on animal disease models such as
sepsis and asthma. The effects of PLAG supplementation
on immune modulation were assessed in healthy men and
women. The objective was to evaluate the effects of PLAG
supplementation on immune regulatory functions such as
activities of immune cells and cytokine production. A randomized
double blind placebo-controlled trial was conducted.
Seventy-five participants were assigned to one of
two groups; all participants had an appropriate number of
white blood cells on the testing day. The PLAG group
(n=27) received oral PLAG supplements and the control
group (n=22) received oral soybean oil supplements. IL-4
and IL-6 production by peripheral blood mononuclear cells
(PBMC) were lower (p<0.001 and p<0.001, respectively)
with PLAG than with soybean oil. However, the production
of IL-2 and IFN-γ by PBMC was unaltered with
PLAG supplementation. The B cell proliferation decreased
significantly in the PLAG group compared to the soybean
oil control (p<0.05). The intake of PLAG in healthy adults for
4 weeks was deemed safe. These data suggest that PLAG
has an immunomodulatory function that inhibits the excessive
immune activity of immunological disorders such
as atopic and autoimmune diseases. PLAG could improve
the condition of these diseases safely as a health food supplement.
[Immune
- Keyword
- HumanLipid supplementNutritionImmunomodulationPLAG (1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol)
- ISSN
- I000-0135
- Publisher
- Korea Soc-Assoc-Inst
- DOI
- http://dx.doi.org/10.4110/in.2015.15.3.150
- Type
- Article
- Appears in Collections:
- Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
- Files in This Item:
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