Mouse hepatic tumor vascular imaging by experimental selective angiography

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Title
Mouse hepatic tumor vascular imaging by experimental selective angiography
Author(s)
S K Kim; H Kim; G Y Koh; D S Lim; Dae Yeul Yu; M D Kim; M S Park; J S Lim
Bibliographic Citation
PLoS One, vol. 10, no. 7, pp. e0131687-e0131687
Publication Year
2015
Abstract
Two new sesquiterpene derivatives (1 and 2), ramarin A (1) and ramarin B (2), together with three known compounds (3-5) were isolated from the fruiting bodies of Ramaria formosa. The structures of the two sesquiterpenes were established by extensive spectroscopic studies and chemical evidence. The inhibitory activity of the isolated compounds (1-5) against human neutrophil elastase (HNE) was evaluated in vitro. All compounds tested inhibited HNE by 35-30% at the highest concentration used (100 μM), whereas the positive control, epigallocatechin gallate (EGCG), exhibited 60% inhibition at 100 μM.
Keyword
GomphaceaeHuman neutrophil elastaseRamaria formosaSesquiterpene
ISSN
1932-6203
Publisher
Public Library of Science
DOI
http://dx.doi.org/10.1248/cpb.c15-00051
Type
Article
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