DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sung Jin Yoon | - |
dc.contributor.author | Jun-Young Park | - |
dc.contributor.author | Song Choi | - |
dc.contributor.author | Jin-Bong Lee | - |
dc.contributor.author | Haiyoung Jung | - |
dc.contributor.author | Tae-Don Kim | - |
dc.contributor.author | Suk Ran Yoon | - |
dc.contributor.author | In Pyo Choi | - |
dc.contributor.author | S Shim | - |
dc.contributor.author | Young-Jun Park | - |
dc.date.accessioned | 2017-04-19T10:07:50Z | - |
dc.date.available | 2017-04-19T10:07:50Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | 10.1016/j.bbrc.2015.06.080 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/12702 | - |
dc.description.abstract | Ginsenoside Rg3, a specific biological effector, is well-known as a major bioactive ingredient of Panax ginseng. However, its role in the inflammasome activation process remains unclear. In this report, we demonstrate that ginsenosides 20(R)-Rg3 and 20(S)-Rg3 are capable of suppressing both lethal endotoxic shock and the S-nitrosylation of the NLRP3 inflammasome by inhibiting nitric oxide (NO) production through the regulation of inducible nitric oxide synthase (iNOS) expression. In response to lipopolysaccharide (LPS), the reducing effect of 20(S)-Rg3 and 20(R)-Rg3 on nitric oxide led to an increase in the survival time of mice after lethal endotoxin-induced shock, and excess levels of NO inhibited IL-1β production via the S-nitrosylation of the NLRP3 inflammasome. In addition, ginsenosides 20(R)-Rg3 and 20(S)-Rg3 had suppressive effects on the LPS- or UV-irradiation-induced reactive oxygen species (ROS) levels in macrophage and HaCaT cells and thereby prevented apoptosis of spleen cells in mice. Altogether, these results demonstrate that ginsenoside 20(R)-Rg3 and 20(S)-Rg3, a naturally occurring compound, might act as a dual therapeutic regulator for the treatment of inflammatory and oxidative stress-related diseases. | - |
dc.publisher | Elsevier | - |
dc.title | Ginsenoside Rg3 regulates S-nitrosylation of the NLRP3 inflammasome via suppression of iNOS = iNOS의 억제를 통한 진세노사이드 Rg3의 역할 | - |
dc.title.alternative | Ginsenoside Rg3 regulates S-nitrosylation of the NLRP3 inflammasome via suppression of iNOS | - |
dc.type | Article | - |
dc.citation.title | Biochemical and Biophysical Research Communications | - |
dc.citation.number | 4 | - |
dc.citation.endPage | 1189 | - |
dc.citation.startPage | 1184 | - |
dc.citation.volume | 463 | - |
dc.contributor.affiliatedAuthor | Sung Jin Yoon | - |
dc.contributor.affiliatedAuthor | Jun-Young Park | - |
dc.contributor.affiliatedAuthor | Song Choi | - |
dc.contributor.affiliatedAuthor | Jin-Bong Lee | - |
dc.contributor.affiliatedAuthor | Haiyoung Jung | - |
dc.contributor.affiliatedAuthor | Tae-Don Kim | - |
dc.contributor.affiliatedAuthor | Suk Ran Yoon | - |
dc.contributor.affiliatedAuthor | In Pyo Choi | - |
dc.contributor.affiliatedAuthor | Young-Jun Park | - |
dc.contributor.alternativeName | 윤성진 | - |
dc.contributor.alternativeName | 박준영 | - |
dc.contributor.alternativeName | 최 송 | - |
dc.contributor.alternativeName | 이진봉 | - |
dc.contributor.alternativeName | 정해용 | - |
dc.contributor.alternativeName | 김태돈 | - |
dc.contributor.alternativeName | 윤석란 | - |
dc.contributor.alternativeName | 최인표 | - |
dc.contributor.alternativeName | 심성보 | - |
dc.contributor.alternativeName | 박영준 | - |
dc.identifier.bibliographicCitation | Biochemical and Biophysical Research Communications, vol. 463, no. 4, pp. 1184-1189 | - |
dc.identifier.doi | 10.1016/j.bbrc.2015.06.080 | - |
dc.subject.keyword | Ginsenoside Rg3 | - |
dc.subject.keyword | iNOS | - |
dc.subject.keyword | NLRP3 inflammasome | - |
dc.subject.keyword | NO | - |
dc.subject.keyword | S-nitrosylation | - |
dc.subject.local | ginsenoside Rg3 | - |
dc.subject.local | Ginsenoside Rg3 | - |
dc.subject.local | Inducible nitric oxide synthase (iNOS) | - |
dc.subject.local | Inducible nitric oxide synthase | - |
dc.subject.local | inducible nnitric oxide synthase | - |
dc.subject.local | iNOS | - |
dc.subject.local | Inducible nitric oxide synthease (iNOS) | - |
dc.subject.local | INOS | - |
dc.subject.local | inducible nitric oxide synthase | - |
dc.subject.local | NLRP3 inflammasome | - |
dc.subject.local | NO | - |
dc.subject.local | nitric oxide | - |
dc.subject.local | nitric oxide (NO) | - |
dc.subject.local | Nitric oxide | - |
dc.subject.local | NO (Nitric oxide) | - |
dc.subject.local | nitric oxide. | - |
dc.subject.local | Nitric oxid | - |
dc.subject.local | Nitric oxide (NO) | - |
dc.subject.local | S-nitrosylation | - |
dc.description.journalClass | Y | - |
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