Ginsenoside Rg3 regulates S-nitrosylation of the NLRP3 inflammasome via suppression of iNOS = iNOS의 억제를 통한 진세노사이드 Rg3의 역할

Cited 70 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorSung Jin Yoon-
dc.contributor.authorJun-Young Park-
dc.contributor.authorSong Choi-
dc.contributor.authorJin-Bong Lee-
dc.contributor.authorHaiyoung Jung-
dc.contributor.authorTae-Don Kim-
dc.contributor.authorSuk Ran Yoon-
dc.contributor.authorIn Pyo Choi-
dc.contributor.authorS Shim-
dc.contributor.authorYoung-Jun Park-
dc.date.accessioned2017-04-19T10:07:50Z-
dc.date.available2017-04-19T10:07:50Z-
dc.date.issued2015-
dc.identifier.issn0006-291X-
dc.identifier.uri10.1016/j.bbrc.2015.06.080ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/12702-
dc.description.abstractGinsenoside Rg3, a specific biological effector, is well-known as a major bioactive ingredient of Panax ginseng. However, its role in the inflammasome activation process remains unclear. In this report, we demonstrate that ginsenosides 20(R)-Rg3 and 20(S)-Rg3 are capable of suppressing both lethal endotoxic shock and the S-nitrosylation of the NLRP3 inflammasome by inhibiting nitric oxide (NO) production through the regulation of inducible nitric oxide synthase (iNOS) expression. In response to lipopolysaccharide (LPS), the reducing effect of 20(S)-Rg3 and 20(R)-Rg3 on nitric oxide led to an increase in the survival time of mice after lethal endotoxin-induced shock, and excess levels of NO inhibited IL-1β production via the S-nitrosylation of the NLRP3 inflammasome. In addition, ginsenosides 20(R)-Rg3 and 20(S)-Rg3 had suppressive effects on the LPS- or UV-irradiation-induced reactive oxygen species (ROS) levels in macrophage and HaCaT cells and thereby prevented apoptosis of spleen cells in mice. Altogether, these results demonstrate that ginsenoside 20(R)-Rg3 and 20(S)-Rg3, a naturally occurring compound, might act as a dual therapeutic regulator for the treatment of inflammatory and oxidative stress-related diseases.-
dc.publisherElsevier-
dc.titleGinsenoside Rg3 regulates S-nitrosylation of the NLRP3 inflammasome via suppression of iNOS = iNOS의 억제를 통한 진세노사이드 Rg3의 역할-
dc.title.alternativeGinsenoside Rg3 regulates S-nitrosylation of the NLRP3 inflammasome via suppression of iNOS-
dc.typeArticle-
dc.citation.titleBiochemical and Biophysical Research Communications-
dc.citation.number4-
dc.citation.endPage1189-
dc.citation.startPage1184-
dc.citation.volume463-
dc.contributor.affiliatedAuthorSung Jin Yoon-
dc.contributor.affiliatedAuthorJun-Young Park-
dc.contributor.affiliatedAuthorSong Choi-
dc.contributor.affiliatedAuthorJin-Bong Lee-
dc.contributor.affiliatedAuthorHaiyoung Jung-
dc.contributor.affiliatedAuthorTae-Don Kim-
dc.contributor.affiliatedAuthorSuk Ran Yoon-
dc.contributor.affiliatedAuthorIn Pyo Choi-
dc.contributor.affiliatedAuthorYoung-Jun Park-
dc.contributor.alternativeName윤성진-
dc.contributor.alternativeName박준영-
dc.contributor.alternativeName최 송-
dc.contributor.alternativeName이진봉-
dc.contributor.alternativeName정해용-
dc.contributor.alternativeName김태돈-
dc.contributor.alternativeName윤석란-
dc.contributor.alternativeName최인표-
dc.contributor.alternativeName심성보-
dc.contributor.alternativeName박영준-
dc.identifier.bibliographicCitationBiochemical and Biophysical Research Communications, vol. 463, no. 4, pp. 1184-1189-
dc.identifier.doi10.1016/j.bbrc.2015.06.080-
dc.subject.keywordGinsenoside Rg3-
dc.subject.keywordiNOS-
dc.subject.keywordNLRP3 inflammasome-
dc.subject.keywordNO-
dc.subject.keywordS-nitrosylation-
dc.subject.localginsenoside Rg3-
dc.subject.localGinsenoside Rg3-
dc.subject.localInducible nitric oxide synthase (iNOS)-
dc.subject.localInducible nitric oxide synthase-
dc.subject.localinducible nnitric oxide synthase-
dc.subject.localiNOS-
dc.subject.localInducible nitric oxide synthease (iNOS)-
dc.subject.localINOS-
dc.subject.localinducible nitric oxide synthase-
dc.subject.localNLRP3 inflammasome-
dc.subject.localNO-
dc.subject.localnitric oxide-
dc.subject.localnitric oxide (NO)-
dc.subject.localNitric oxide-
dc.subject.localNO (Nitric oxide)-
dc.subject.localnitric oxide.-
dc.subject.localNitric oxid-
dc.subject.localNitric oxide (NO)-
dc.subject.localS-nitrosylation-
dc.description.journalClassY-
Appears in Collections:
Division of Research on National Challenges > Environmental diseases research center > 1. Journal Articles
Aging Convergence Research Center > 1. Journal Articles
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.