DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hyunjoo Cha | - |
dc.contributor.author | K S Sung | - |
dc.contributor.author | Joonsung Hwang | - |
dc.contributor.author | Kyeong A Kim | - |
dc.contributor.author | Ji-eun Yu | - |
dc.contributor.author | Y D Yoo | - |
dc.contributor.author | J M Jang | - |
dc.contributor.author | D H Han | - |
dc.contributor.author | M Molstad | - |
dc.contributor.author | Jung Gi Kim | - |
dc.contributor.author | Y J Lee | - |
dc.contributor.author | A Zakrzewska | - |
dc.contributor.author | Su Hyeon Kim | - |
dc.contributor.author | S T Kim | - |
dc.contributor.author | S Y Kim | - |
dc.contributor.author | Hee Gu Lee | - |
dc.contributor.author | Nak Kyun Soung | - |
dc.contributor.author | Jong Seog Ahn | - |
dc.contributor.author | A Ciechanover | - |
dc.contributor.author | Bo Yeon Kim | - |
dc.contributor.author | Y T Kwon | - |
dc.date.accessioned | 2017-04-19T10:08:41Z | - |
dc.date.available | 2017-04-19T10:08:41Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1465-7392 | - |
dc.identifier.uri | 10.1038/ncb3177 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/12722 | - |
dc.description.abstract | We show that ATE1-encoded Arg-transfer RNA transferase (R-transferase) of the N-end rule pathway mediates N-terminal arginylation of multiple endoplasmic reticulum (ER)-residing chaperones, leading to their cytosolic relocalization and turnover. N-terminal arginylation of BiP (also known as GRP78), protein disulphide isomerase and calreticulin is co-induced with autophagy during innate immune responses to cytosolic foreign DNA or proteasomal inhibition, associated with increased ubiquitylation. Arginylated BiP (R-BiP) is induced by and associated with cytosolic misfolded proteins destined for p62 (also known as sequestosome 1, SQSTM1) bodies. R-BiP binds the autophagic adaptor p62 through the interaction of its N-terminal arginine with the p62 ZZ domain. This allosterically induces self-oligomerization and aggregation of p62 and increases p62 interaction with LC3, leading to p62 targeting to autophagosomes and selective lysosomal co-degradation of R-BiP and p62 together with associated cargoes. In this autophagic mechanism, Nt-arginine functions as a delivery determinant, a degron and an activating ligand. Bioinformatics analysis predicts that many ER residents use arginylation to regulate non-ER processes. | - |
dc.publisher | Springer-Nature Pub Group | - |
dc.title | Amino-terminal arginylation targets endoplasmic reticulum chaperone BiP for autophagy through p62 binding | - |
dc.title.alternative | Amino-terminal arginylation targets endoplasmic reticulum chaperone BiP for autophagy through p62 binding | - |
dc.type | Article | - |
dc.citation.title | Nature Cell Biology | - |
dc.citation.number | 7 | - |
dc.citation.endPage | 929 | - |
dc.citation.startPage | 917 | - |
dc.citation.volume | 17 | - |
dc.contributor.affiliatedAuthor | Hyunjoo Cha | - |
dc.contributor.affiliatedAuthor | Joonsung Hwang | - |
dc.contributor.affiliatedAuthor | Kyeong A Kim | - |
dc.contributor.affiliatedAuthor | Ji-eun Yu | - |
dc.contributor.affiliatedAuthor | Jung Gi Kim | - |
dc.contributor.affiliatedAuthor | Su Hyeon Kim | - |
dc.contributor.affiliatedAuthor | Hee Gu Lee | - |
dc.contributor.affiliatedAuthor | Nak Kyun Soung | - |
dc.contributor.affiliatedAuthor | Jong Seog Ahn | - |
dc.contributor.affiliatedAuthor | Bo Yeon Kim | - |
dc.contributor.alternativeName | 차현주 | - |
dc.contributor.alternativeName | 성기사 | - |
dc.contributor.alternativeName | 황준성 | - |
dc.contributor.alternativeName | 김경아 | - |
dc.contributor.alternativeName | 유지은 | - |
dc.contributor.alternativeName | 유영동 | - |
dc.contributor.alternativeName | 장준민 | - |
dc.contributor.alternativeName | 한동훈 | - |
dc.contributor.alternativeName | Molstad | - |
dc.contributor.alternativeName | 김정기 | - |
dc.contributor.alternativeName | 이윤지 | - |
dc.contributor.alternativeName | Zakrzewska | - |
dc.contributor.alternativeName | 김수현 | - |
dc.contributor.alternativeName | 김성태 | - |
dc.contributor.alternativeName | 김선용 | - |
dc.contributor.alternativeName | 이희구 | - |
dc.contributor.alternativeName | 성낙균 | - |
dc.contributor.alternativeName | 안종석 | - |
dc.contributor.alternativeName | Ciechanover | - |
dc.contributor.alternativeName | 김보연 | - |
dc.contributor.alternativeName | 권용태 | - |
dc.identifier.bibliographicCitation | Nature Cell Biology, vol. 17, no. 7, pp. 917-929 | - |
dc.identifier.doi | 10.1038/ncb3177 | - |
dc.description.journalClass | Y | - |
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