Roles of DPY30 in the proliferation and motility of gastric cancer cells

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Title
Roles of DPY30 in the proliferation and motility of gastric cancer cells
Author(s)
Y J Lee; M E Han; Su Jin Baek; Seon-Young Kim; S O Oh
Bibliographic Citation
PLoS One, vol. 10, no. 7, pp. e0131863-e0131863
Publication Year
2015
Abstract
Various types of histone methylation have been associated with cancer progression. Depending on the methylation site in histone proteins, its effects on transcription are different. DPY30 is a common member of SET1/MLL histone H3K4 methyltransferase complexes. However, its expression and roles in gastric cancer have been poorly characterized. To determine whether DPY30 has pathophysiological roles in gastric cancer, its expression and roles were examined. Immunohistochemistry and real time PCR showed up-regulation of DPY30 expression in some gastric cancer cell lines and patients' tissues. Its knockdown by siRNA decreased the proliferation, migration, and invasion of gastric cancer cells, whereas its overexpression showed the opposite effects. These results indicate that DPY30 has critical roles in the proliferation, migration, and invasion of gastric cancer cells, and suggest DPY30 might be a therapeutic target in gastric cancer.
ISSN
1932-6203
Publisher
Public Library of Science
DOI
http://dx.doi.org/10.1371/journal.pone.0131863
Type
Article
Appears in Collections:
Korea Bioinformation Center > 1. Journal Articles
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