Organization of the mammalian metabolome according to organ function, lineage specialization, and longevity

Cited 60 time in scopus
Metadata Downloads
Title
Organization of the mammalian metabolome according to organ function, lineage specialization, and longevity
Author(s)
S Ma; S H Yim; S G Lee; E B Kim; Sang-Rae Lee; Kyu Tae Chang; R Buffenstein; K N Lewis; T J Park; R A Miller; C B Clish; V N Gladyshev
Bibliographic Citation
Cell Metabolism, vol. 22, no. 2, pp. 332-343
Publication Year
2015
Abstract
Biological diversity among mammals is remarkable. Mammalian body weights range seven orders of magnitude and lifespans differ more than 100-fold among species. While genetic, dietary, and pharmacological interventions can be used to modulate these traits in model organisms, it is unknown how they are determined by natural selection. By profiling metabolites in brain, heart, kidney, and liver tissues of 26 mammalian species representing ten taxonomical orders, we report metabolite patterns characteristic of organs, lineages, and species longevity. Our data suggest different rates of metabolite divergence across organs and reveal patterns representing organ-specific functions and lineage-specific physiologies. We identified metabolites that correlated with species lifespan, some of which were previously implicated in longevity control. We also compared the results with metabolite changes in five long-lived mouse models and observed some similar patterns. Overall, this study describes adjustments of the mammalian metabolome according to lifespan, phylogeny, and organ and lineage specialization.
ISSN
1550-4131
Publisher
Elsevier-Cell Press
DOI
http://dx.doi.org/10.1016/j.cmet.2015.07.005
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > National Primate Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.