Eupafolin suppresses prostate cancer by targeting phosphatidylinositol 3-kinase-mediated Akt signaling

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dc.contributor.authorK Liu-
dc.contributor.authorChanmi Park-
dc.contributor.authorH Chen-
dc.contributor.authorJoonsung Hwang-
dc.contributor.authorN R Thimmegowda-
dc.contributor.authorEun Young Bae-
dc.contributor.authorKi Won Lee-
dc.contributor.authorH G Kim-
dc.contributor.authorH Liu-
dc.contributor.authorNak Kyun Soung-
dc.contributor.authorC Peng-
dc.contributor.authorJae-Hyuk Jang-
dc.contributor.authorK E Kim-
dc.contributor.authorJong Seog Ahn-
dc.contributor.authorA M Bode-
dc.contributor.authorZ Dong-
dc.contributor.authorKim Bo Yeon-
dc.contributor.authorZ Dong-
dc.date.accessioned2017-04-19T10:10:29Z-
dc.date.available2017-04-19T10:10:29Z-
dc.date.issued2015-
dc.identifier.issn08991987-
dc.identifier.uri10.1002/mc.22139ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/12793-
dc.description.abstractPhosphatase and tensin homolog (PTEN) loss or mutation consistently activates the phosphatidylinositol 3-kinase (PI3-K)/Akt signaling pathway, which contributes to the progression and invasiveness of prostate cancer. Furthermore, the PTEN/PI3-K/Akt and Ras/MAPK pathways cooperate to promote the epithelial-mesenchymal transition (EMT) and metastasis initiated from prostate stem/progenitor cells. For these reasons, the PTEN/PI3-K/Akt pathway is considered as an attractive target for both chemoprevention and chemotherapy. Herein we report that eupafolin, a natural compound found in common sage, inhibited proliferation of prostate cancer cells. Protein content analysis indicated that phosphorylation of Akt and its downstream kinases was inhibited by eupafolin treatment. Pull-down assay and in vitro kinase assay results indicated that eupafolin could bind with PI3-K and attenuate its kinase activity. Eupafolin also exhibited tumor suppressive effects in vivo in an athymic nude mouse model. Overall, these results suggested that eupafolin exerts antitumor effects by targeting PI3-K.-
dc.publisherWiley-
dc.titleEupafolin suppresses prostate cancer by targeting phosphatidylinositol 3-kinase-mediated Akt signaling-
dc.title.alternativeEupafolin suppresses prostate cancer by targeting phosphatidylinositol 3-kinase-mediated Akt signaling-
dc.typeArticle-
dc.citation.titleMolecular Carcinogenesis-
dc.citation.number9-
dc.citation.endPage760-
dc.citation.startPage751-
dc.citation.volume54-
dc.contributor.affiliatedAuthorJoonsung Hwang-
dc.contributor.affiliatedAuthorNak Kyun Soung-
dc.contributor.affiliatedAuthorJae-Hyuk Jang-
dc.contributor.affiliatedAuthorJong Seog Ahn-
dc.contributor.affiliatedAuthorKim Bo Yeon-
dc.contributor.alternativeNameLiu-
dc.contributor.alternativeName박찬미-
dc.contributor.alternativeNameChen-
dc.contributor.alternativeName황준성-
dc.contributor.alternativeNameThimmegowda-
dc.contributor.alternativeName배은영-
dc.contributor.alternativeName이기원-
dc.contributor.alternativeName김홍겸-
dc.contributor.alternativeNameLiu-
dc.contributor.alternativeName성낙균-
dc.contributor.alternativeNamePeng-
dc.contributor.alternativeName장재혁-
dc.contributor.alternativeName김균언-
dc.contributor.alternativeName안종석-
dc.contributor.alternativeNameBode-
dc.contributor.alternativeNameDong-
dc.contributor.alternativeName김보연-
dc.contributor.alternativeNameDong-
dc.identifier.bibliographicCitationMolecular Carcinogenesis, vol. 54, no. 9, pp. 751-760-
dc.identifier.doi10.1002/mc.22139-
dc.subject.keywordAkt-
dc.subject.keywordChemoprevention-
dc.subject.keywordEupafolin-
dc.subject.keywordPhosphatidylinositol 3-kinase-
dc.subject.keywordProstate cancer-
dc.subject.localAkt-
dc.subject.localChemoprevention-
dc.subject.localEupafolin-
dc.subject.localPhosphatidylinositol 3-kinase-
dc.subject.localProstate cancer-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
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