Ulleungamides A and B, modified α,β-dehydropipecolic acid containing cyclic depsipeptides from Streptomyces sp. KCB13F003

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Title
Ulleungamides A and B, modified α,β-dehydropipecolic acid containing cyclic depsipeptides from Streptomyces sp. KCB13F003
Author(s)
Sangkeun Son; Sung-Kyun Ko; Mina Jang; Jae Kyoung Lee; In Ja RyooJung-Sook LeeKyung Ho LeeNak Kyun Soung; H Oh; Young-Soo HongBo Yeon KimJae-Hyuk JangJong Seog Ahn
Bibliographic Citation
Organic Letters, vol. 17, no. 16, pp. 4046-4049
Publication Year
2015
Abstract
Two novel cyclic depsipeptides, ulleungamides A (1) and B (2), were isolated from cultures of terrestrial Streptomyces sp. Their structures were determined by analyses of spectroscopic data and various chemical transformations, including modified Mosher's method, advanced Marfey's method, PGME, GITC derivatizations, and Snatzke's method. Ulleungamides were determined to be a new class of peptides bearing unprecedented units, such as 5-hydroxy-6-methyl-2,3-dehydropipecolic acid, 4,5-dihydroxy-6-methyl-2,3-dehydropipecolic acid, and amino-linked 2-isopropylsuccinic acid. Ulleungamide A displayed growth inhibitory activity against Staphylococcus aureus and Salmonella typhimurium without cytotoxicity.
ISSN
1523-7060
Publisher
Amer Chem Soc
DOI
http://dx.doi.org/10.1021/acs.orglett.5b01969
Type
Article
Appears in Collections:
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
Jeonbuk Branch Institute > Biological Resource Center > 1. Journal Articles
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