Polyethylenimine-poly(amidoamine) dendrimer modified with l-arginines as an efficient gene delivery vector

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dc.contributor.authorN Y Ahn-
dc.contributor.authorT H Kim-
dc.contributor.authorS J Song-
dc.contributor.authorJ M Moon-
dc.contributor.authorTai Hwan Ha-
dc.contributor.authorJ S Choi-
dc.date.accessioned2017-04-19T10:10:39Z-
dc.date.available2017-04-19T10:10:39Z-
dc.date.issued2015-
dc.identifier.issn15985032-
dc.identifier.uri10.1007/s13233-015-3101-6ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/12809-
dc.description.abstractIn this study, we synthesized polyethylenimine-polyamidoamine-arginine dendritic polymers (PPRs) as vectors for gene delivery. Four polymers, polyethylenimine-polyamidoamine generation 1 (PP1), PP2, PP1-arginine (PP1R), and PP2-arginine (PP2R), were synthesized and confirmed by 1H NMR. PPRs were shown to interact with and condense plasmid DNA effectively to form 171-179 nm polyplexes with 30-32 mV of zeta potentials at weight ratio 4:1 (polymer:plasmid DNA). Cytotoxicity of PPRs/pDNA complexes was lower than that of polyethylenimine (PEI) 25 kDa/pDNA complexes for all concentration ranges tested. In 293 cells, PP1R/pDNA complexes showed higher gene transfection efficiency than PEI 25 kDa. These results suggest that PPR could be promising dendritic gene carriers for gene therapy.[Figure not available: see fulltext.]-
dc.publisherPolymer Soc Korea-
dc.titlePolyethylenimine-poly(amidoamine) dendrimer modified with l-arginines as an efficient gene delivery vector-
dc.title.alternativePolyethylenimine-poly(amidoamine) dendrimer modified with l-arginines as an efficient gene delivery vector-
dc.typeArticle-
dc.citation.titleMacromolecular Research-
dc.citation.number8-
dc.citation.endPage733-
dc.citation.startPage726-
dc.citation.volume23-
dc.contributor.affiliatedAuthorTai Hwan Ha-
dc.contributor.alternativeName안난영-
dc.contributor.alternativeName김태훈-
dc.contributor.alternativeName송수정-
dc.contributor.alternativeName문정미-
dc.contributor.alternativeName하태환-
dc.contributor.alternativeName최준식-
dc.identifier.bibliographicCitationMacromolecular Research, vol. 23, no. 8, pp. 726-733-
dc.identifier.doi10.1007/s13233-015-3101-6-
dc.subject.keyworddendrimer-
dc.subject.keywordL-arginine-
dc.subject.keywordnanoparticles-
dc.subject.keywordpoly(amidoamine)-
dc.subject.keywordpolyethylenimine-
dc.subject.localdendrimer-
dc.subject.localDendrimer-
dc.subject.localL-arginine-
dc.subject.localnanoparticles-
dc.subject.localpoly(amidoamine)-
dc.subject.localpolyethylenimine-
dc.subject.localPolyethylenimine-
dc.description.journalClassY-
Appears in Collections:
Division of Biomaterials Research > Bionanotechnology Research Center > 1. Journal Articles
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