Heme oxygenase-1 accelerates erastin-induced ferroptotic cell death

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dc.contributor.authorM Y Kwon-
dc.contributor.authorE Park-
dc.contributor.authorSeon-Jin Lee-
dc.contributor.authorS W Chung-
dc.date.accessioned2017-04-19T10:12:14Z-
dc.date.available2017-04-19T10:12:14Z-
dc.date.issued2015-
dc.identifier.issn19492553-
dc.identifier.uri10.18632/oncotarget.5162ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/12855-
dc.description.abstractThe oncogenic RAS-selective lethal small molecule Erastin triggers a unique iron-dependent form of nonapoptotic cell death termed ferroptosis. Ferroptosis is dependent upon the production of intracellular iron-dependent reactive oxygen species (ROS), but not other metals. However, key regulators remain unknown. The heme oxygenase (HO) is a major intracellular source of iron. In this study, the role of heme oxygenase in Erastin-triggered ferroptotic cancer cell death has been investigated. Zinc protoporphyrin IX (ZnPP), a HO-1 inhibitor, prevented Erastin-triggered ferroptotic cancer cell death. Furthermore, Erastin induced the protein and mRNA levels of HO-1 in HT-1080 fibrosarcoma cells. HO-1+/+ and HO-1-/- fibroblast, HO-1 overexpression, and chycloheximide-treated experiments revealed that the expression of HO-1 has a decisive effects in Erastin-triggered cell death. Hemin and CO-releasing molecules (CORM) promote Erastin-induced ferroptotic cell death, not by biliverdin and bilirubin. In addition, hemin and CORM accelerate the HO-1 expression in the presence of Erastin and increase membranous lipid peroxidation. Thus, HO-1 is an essential enzyme for iron-dependent lipid peroxidation during ferroptotic cell death.-
dc.publisherImpact Journalsko
dc.titleHeme oxygenase-1 accelerates erastin-induced ferroptotic cell death-
dc.title.alternativeHeme oxygenase-1 accelerates erastin-induced ferroptotic cell death-
dc.typeArticle-
dc.citation.titleOncotarget-
dc.citation.number27-
dc.citation.endPage24403-
dc.citation.startPage24393-
dc.citation.volume6-
dc.contributor.affiliatedAuthorSeon-Jin Lee-
dc.contributor.alternativeName권민영-
dc.contributor.alternativeName박은희-
dc.contributor.alternativeName이선진-
dc.contributor.alternativeName정수월-
dc.identifier.bibliographicCitationOncotarget, vol. 6, no. 27, pp. 24393-24403-
dc.identifier.doi10.18632/oncotarget.5162-
dc.subject.keywordFree radicals-
dc.subject.keywordHeme oxygenase-1-
dc.subject.keywordIron-
dc.subject.keywordOncogene-
dc.subject.keywordOncology-
dc.subject.localFree radicals-
dc.subject.localfree radical-
dc.subject.localHeme oxygenase-1-
dc.subject.localIron-
dc.subject.localOncogene-
dc.subject.localOncology-
dc.description.journalClassN-
Appears in Collections:
Division of Research on National Challenges > Environmental diseases research center > 1. Journal Articles
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