Silica nanoparticles inhibit brown adipocyte differentiation via regulation of p38 phosphorylation

Cited 9 time in scopus
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Title
Silica nanoparticles inhibit brown adipocyte differentiation via regulation of p38 phosphorylation
Author(s)
Min Jeong Son; Won Kon Kim; M Kwak; Kyoung Jin Oh; W S Chang; Jeong Ki MinSang Chul Lee; N W Song; Kwang-Hee Bae
Bibliographic Citation
Nanotechnology, vol. 26, no. 43, pp. 435101-435101
Publication Year
2015
Abstract
Nanoparticles are of great interest due to their wide variety of biomedical and bioengineering applications. However, they affect cellular differentiation and/or intracellular signaling when applied and exposed to target organisms or cells. The brown adipocyte is a cell type important in energy homeostasis and thus closely related to obesity. In this study, we assessed the effects of silica nanoparticles (SNPs) on brown adipocyte differentiation. The results clearly showed that brown adipocyte differentiation was significantly repressed by exposure to SNPs. The brown adipocyte-specific genes as well as mitochondrial content were also markedly reduced. Additionally, SNPs led to suppressed p38 phosphorylation during brown adipocyte differentiation. These effects depend on the size of SNPs. Taken together, these results lead us to suggest that SNP has anti-brown adipogenic effect in a size-dependent manner via regulation of p38 phosphorylation.
Keyword
brown adipogenesisnanotoxicityp38silica nanoparticles
ISSN
0957-4484
Publisher
IOP Publishing Ltd
DOI
http://dx.doi.org/10.1088/0957-4484/26/43/435101
Type
Article
Appears in Collections:
Division of Biomedical Research > Metabolic Regulation Research Center > 1. Journal Articles
Division of Biomedical Research > Biotherapeutics Translational Research Center > 1. Journal Articles
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