Neo-clerodane diterpenoids from Scutellaria barbata and their inhibitory effects on LPS-induced nitric oxide production
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- Title
- Neo-clerodane diterpenoids from Scutellaria barbata and their inhibitory effects on LPS-induced nitric oxide production
- Author(s)
- E T Yeon; J W Lee; C Lee; Q Jin; H Jang; D Lee; Jong Seog Ahn; J T Hong; Y Kim; M K Lee; B Y Hwang
- Bibliographic Citation
- Journal of Natural Products, vol. 78, no. 9, pp. 2292-2296
- Publication Year
- 2015
- Abstract
- Three new neo-clerodane diterpenoids (1-3) along with 12 known compounds (4-15) were isolated from a methanol extract of the aerial parts of Scutellaria barbata. The structures of 1-3 were determined by interpretation of their 1D and 2D NMR spectroscopic data as well as HRESIMS values. All isolated compounds were tested for their inhibitory effects on LPS-induced nitric oxide production in RAW 264.7 macrophages. Compounds 1-4, 7, and 10-12 were found to inhibit nitric oxide production with IC50 values ranging from 20.2 to 35.6 M.
- ISSN
- 0163-3864
- Publisher
- Amer Chem Soc
- Full Text Link
- http://dx.doi.org/10.1021/acs.jnatprod.5b00126
- Type
- Article
- Appears in Collections:
- Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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