MKP kinase phosphatase 3 inhibits brown adipocyte differentiation via regulation of Erk phosphorylation

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Title
MKP kinase phosphatase 3 inhibits brown adipocyte differentiation via regulation of Erk phosphorylation
Author(s)
Won Kon KimKyoung Jin Oh; Hye Ryung Choi; Anna Park; Baek Soo HanSeung-Wook ChiSeung Jun KimKwang-Hee Bae; Sang Chul Lee
Bibliographic Citation
Molecular and Cellular Endocrinology, vol. 416, pp. 70-76
Publication Year
2015
Abstract
Brown fat has been highlight as a new therapeutic target for treatment of obesity and diabetes. However, molecular mechanism underlying brown adipogenesis are not fully understood. Here, we identified that MAP kinase phosphatase 3 (MKP3) has a novel role as regulator of brown adipocyte differentiation. The expression of MKP3 was significantly decreased during the early stage(s) of brown adipocyte differentiation in HIB-1B cells and primary cells. Ectopic expression of MKP3 led to reduced brown adipocyte differentiation, whereas depletion of MKP3 significantly enhanced the differentiation of primary brown preadipocytes. Consistently, we found an increased brown adipocyte differentiation in MKP3-null MEF cells. These inhibitory effects of MKP3 could be resulted via the temporal regulation of Erk activation. In recent, it was reported that MKP3 deficient mice are resistant to diet-induced obesity, and display enhanced energy expenditure. Taken together, we suggest that MKP3 could be an important factor in the regulation of brown adipocyte differentiation.
Keyword
Brown adipogenesisERKMKP3Obesity
ISSN
0303-7207
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.mce.2015.08.023.
Type
Article
Appears in Collections:
Division of Biomedical Research > Metabolic Regulation Research Center > 1. Journal Articles
Division of Research on National Challenges > Biodefense Research Center > 1. Journal Articles
Division of Biomedical Research > 1. Journal Articles
Critical Diseases Diagnostics Convergence Research Center > 1. Journal Articles
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