6-O-Veratroyl catalpol suppresses pro-inflammatory cytokines via regulation of extracellular signal-regulated kinase and nuclear factor-κB in human monocytic cells

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dc.contributor.authorM Q Le-
dc.contributor.authorM S Kim-
dc.contributor.authorY S Song-
dc.contributor.authorHyung Won Ryu-
dc.contributor.authorSei-Ryang Oh-
dc.contributor.authorD Y Yoon-
dc.date.accessioned2017-04-19T10:13:26Z-
dc.date.available2017-04-19T10:13:26Z-
dc.date.issued2015-
dc.identifier.issn0300-9084-
dc.identifier.uri10.1016/j.biochi.2015.10.006ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/12915-
dc.description.abstractThe compound 6-O-veratroyl catalpol (6-O) is a bioactive iridoid glucoside that was originally isolated from Pseudolysimachion rotundum var. subintegrum. It has been demonstrated that catapol derivative iridoid glucosides including 6-O, possess anti-inflammatory activity in carragenan-induced paw edema mouse model as well as bronchoalveolar lavage fluid of ovalbumin-induced mouse model. In the present study, we investigated whether 6-O modulates inflammatory responses in THP-1 monocytic cells stimulated with phorbol12-myristate-13-acetate (PMA). Our data showed that 6-O inhibited PMA induced interleukin (IL)-1β and tumor necrosis factor (TNF)-α expression in THP-1 monocytic cells. Mechanistic studies revealed that 6-O suppressed the activity of protein kinase C (PKC), which further resulted in downstream inactivation of extracellular signal-regulated kinase (ERK) and nuclear factor-κB (NF-κB) inflammatory pathway. The results implied that 6-O may protect against inflammatory responses that could be a potential compound in treating inflammatory diseases.-
dc.publisherElsevier-
dc.title6-O-Veratroyl catalpol suppresses pro-inflammatory cytokines via regulation of extracellular signal-regulated kinase and nuclear factor-κB in human monocytic cells-
dc.title.alternative6-O-Veratroyl catalpol suppresses pro-inflammatory cytokines via regulation of extracellular signal-regulated kinase and nuclear factor-κB in human monocytic cells-
dc.typeArticle-
dc.citation.titleBiochimie-
dc.citation.number0-
dc.citation.endPage59-
dc.citation.startPage52-
dc.citation.volume119-
dc.contributor.affiliatedAuthorHyung Won Ryu-
dc.contributor.affiliatedAuthorSei-Ryang Oh-
dc.contributor.alternativeNameLe-
dc.contributor.alternativeName김만섭-
dc.contributor.alternativeName송용석-
dc.contributor.alternativeName류형원-
dc.contributor.alternativeName오세량-
dc.contributor.alternativeName윤도영-
dc.identifier.bibliographicCitationBiochimie, vol. 119, pp. 52-59-
dc.identifier.doi10.1016/j.biochi.2015.10.006-
dc.subject.keyword6-O-Veratroyl catalpol-
dc.subject.keywordAnti-inflammation-
dc.subject.keywordPMA-
dc.subject.keywordPro-inflammatory cytokines-
dc.subject.keywordTHP-1 cells-
dc.subject.local6-O-Veratroyl catalpol-
dc.subject.localantiinflammation-
dc.subject.localAntiinflammation-
dc.subject.localanti-inflammation-
dc.subject.localAnti-Inflammation-
dc.subject.localAnti-inflammation-
dc.subject.localPMA-
dc.subject.localproinflammatory cytokine-
dc.subject.localPro-inflammatory cytokine-
dc.subject.localProinflammatory cytokine-
dc.subject.localPro-inflammatory cytokines-
dc.subject.localProinflammatory cytokines-
dc.subject.localpro-inflammatory cytokine-
dc.subject.localTHP-1 cells-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
Ochang Branch Institute > 1. Journal Articles
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