DC Field | Value | Language |
---|---|---|
dc.contributor.author | M Q Le | - |
dc.contributor.author | M S Kim | - |
dc.contributor.author | Y S Song | - |
dc.contributor.author | Hyung Won Ryu | - |
dc.contributor.author | Sei-Ryang Oh | - |
dc.contributor.author | D Y Yoon | - |
dc.date.accessioned | 2017-04-19T10:13:26Z | - |
dc.date.available | 2017-04-19T10:13:26Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0300-9084 | - |
dc.identifier.uri | 10.1016/j.biochi.2015.10.006 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/12915 | - |
dc.description.abstract | The compound 6-O-veratroyl catalpol (6-O) is a bioactive iridoid glucoside that was originally isolated from Pseudolysimachion rotundum var. subintegrum. It has been demonstrated that catapol derivative iridoid glucosides including 6-O, possess anti-inflammatory activity in carragenan-induced paw edema mouse model as well as bronchoalveolar lavage fluid of ovalbumin-induced mouse model. In the present study, we investigated whether 6-O modulates inflammatory responses in THP-1 monocytic cells stimulated with phorbol12-myristate-13-acetate (PMA). Our data showed that 6-O inhibited PMA induced interleukin (IL)-1β and tumor necrosis factor (TNF)-α expression in THP-1 monocytic cells. Mechanistic studies revealed that 6-O suppressed the activity of protein kinase C (PKC), which further resulted in downstream inactivation of extracellular signal-regulated kinase (ERK) and nuclear factor-κB (NF-κB) inflammatory pathway. The results implied that 6-O may protect against inflammatory responses that could be a potential compound in treating inflammatory diseases. | - |
dc.publisher | Elsevier | - |
dc.title | 6-O-Veratroyl catalpol suppresses pro-inflammatory cytokines via regulation of extracellular signal-regulated kinase and nuclear factor-κB in human monocytic cells | - |
dc.title.alternative | 6-O-Veratroyl catalpol suppresses pro-inflammatory cytokines via regulation of extracellular signal-regulated kinase and nuclear factor-κB in human monocytic cells | - |
dc.type | Article | - |
dc.citation.title | Biochimie | - |
dc.citation.number | 0 | - |
dc.citation.endPage | 59 | - |
dc.citation.startPage | 52 | - |
dc.citation.volume | 119 | - |
dc.contributor.affiliatedAuthor | Hyung Won Ryu | - |
dc.contributor.affiliatedAuthor | Sei-Ryang Oh | - |
dc.contributor.alternativeName | Le | - |
dc.contributor.alternativeName | 김만섭 | - |
dc.contributor.alternativeName | 송용석 | - |
dc.contributor.alternativeName | 류형원 | - |
dc.contributor.alternativeName | 오세량 | - |
dc.contributor.alternativeName | 윤도영 | - |
dc.identifier.bibliographicCitation | Biochimie, vol. 119, pp. 52-59 | - |
dc.identifier.doi | 10.1016/j.biochi.2015.10.006 | - |
dc.subject.keyword | 6-O-Veratroyl catalpol | - |
dc.subject.keyword | Anti-inflammation | - |
dc.subject.keyword | PMA | - |
dc.subject.keyword | Pro-inflammatory cytokines | - |
dc.subject.keyword | THP-1 cells | - |
dc.subject.local | 6-O-Veratroyl catalpol | - |
dc.subject.local | antiinflammation | - |
dc.subject.local | Antiinflammation | - |
dc.subject.local | anti-inflammation | - |
dc.subject.local | Anti-Inflammation | - |
dc.subject.local | Anti-inflammation | - |
dc.subject.local | PMA | - |
dc.subject.local | proinflammatory cytokine | - |
dc.subject.local | Pro-inflammatory cytokine | - |
dc.subject.local | Proinflammatory cytokine | - |
dc.subject.local | Pro-inflammatory cytokines | - |
dc.subject.local | Proinflammatory cytokines | - |
dc.subject.local | pro-inflammatory cytokine | - |
dc.subject.local | THP-1 cells | - |
dc.description.journalClass | Y | - |
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