Phosphoprotein phosphatase 1CB (PPP1CB), a novel adipogenic activator, promotes 3T3-L1 adipogenesis

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dc.contributor.authorY L Cho-
dc.contributor.authorJeong Ki Min-
dc.contributor.authorK M Roh-
dc.contributor.authorWon Kon Kim-
dc.contributor.authorBaek Soo Han-
dc.contributor.authorKwang-Hee Bae-
dc.contributor.authorSang Chul Lee-
dc.contributor.authorS J Chung-
dc.contributor.authorH J Kang-
dc.date.accessioned2017-04-19T10:13:26Z-
dc.date.available2017-04-19T10:13:26Z-
dc.date.issued2015-
dc.identifier.issn0006-291X-
dc.identifier.uri10.1016/j.bbrc.2015.10.004ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/12917-
dc.description.abstractUnderstanding the molecular networks that regulate adipogenesis is crucial for gaining insight into obesity and identifying medicinal targets thereof is necessary for pharmacological interventions. However, the identity and molecular actions of activators that promote the early development of adipocytes are still largely unknown. Here, we demonstrate a novel role for phosphoprotein phosphatase 1CB (PPP1CB) as a potent adipogenic activator that promotes adipocyte differentiation. PPP1CB expression increased in vitro during the early phase of 3T3-L1 adipogenesis and in the murine model of high-fat diet-induced obesity. Depletion of PPP1CB dramatically suppressed the differentiation of 3T3-L1 cells into mature adipocytes, with a concomitant change in adipocyte marker genes and significantly inhibited clonal expansion. We also showed that knockdown of PPP1CB caused a significant decrease in C/EBPδ expression, which in turn resulted in attenuation of PPARγ, C/EBPα, adiponectin, and aP2. In addition, we elucidated the functional significance of PPP1CB by linking p38 activation to C/EBPδ expression in early adipogenesis. Overall, our findings demonstrate a novel function of PPP1CB in promoting adipogenesis and suggest that PPP1CB may be a promising therapeutic target for treatment of obesity and obesity-related diseases.-
dc.publisherElsevier-
dc.titlePhosphoprotein phosphatase 1CB (PPP1CB), a novel adipogenic activator, promotes 3T3-L1 adipogenesis-
dc.title.alternativePhosphoprotein phosphatase 1CB (PPP1CB), a novel adipogenic activator, promotes 3T3-L1 adipogenesis-
dc.typeArticle-
dc.citation.titleBiochemical and Biophysical Research Communications-
dc.citation.number2-
dc.citation.endPage217-
dc.citation.startPage211-
dc.citation.volume467-
dc.contributor.affiliatedAuthorJeong Ki Min-
dc.contributor.affiliatedAuthorWon Kon Kim-
dc.contributor.affiliatedAuthorBaek Soo Han-
dc.contributor.affiliatedAuthorKwang-Hee Bae-
dc.contributor.affiliatedAuthorSang Chul Lee-
dc.contributor.alternativeName조영래-
dc.contributor.alternativeName민정기-
dc.contributor.alternativeName노경민-
dc.contributor.alternativeName김원곤-
dc.contributor.alternativeName한백수-
dc.contributor.alternativeName배광희-
dc.contributor.alternativeName이상철-
dc.contributor.alternativeName정상전-
dc.contributor.alternativeName강효진-
dc.identifier.bibliographicCitationBiochemical and Biophysical Research Communications, vol. 467, no. 2, pp. 211-217-
dc.identifier.doi10.1016/j.bbrc.2015.10.004-
dc.subject.keyword3T3-L1 preadipocyte-
dc.subject.keywordAdipogenesis-
dc.subject.keywordC/EBPδ-
dc.subject.keywordp38-
dc.subject.keywordPhosphoprotein phosphatase 1CB-
dc.subject.local3T3-L1 preadipocyte-
dc.subject.local3T3-L1 preadipocytes-
dc.subject.localadipogenesis-
dc.subject.localADIPOGENESIS-
dc.subject.localAdipogenesis-
dc.subject.localC/EBPδ-
dc.subject.localP38-
dc.subject.localp38-
dc.subject.localPhosphoprotein phosphatase 1CB-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Biotherapeutics Translational Research Center > 1. Journal Articles
Division of Biomedical Research > Metabolic Regulation Research Center > 1. Journal Articles
Division of Research on National Challenges > Biodefense Research Center > 1. Journal Articles
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