An ultrasensitive, selective, multiplexed superbioelectronic nose that mimics the human sense of smell

Cited 123 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorOh Seok Kwon-
dc.contributor.authorH S Song-
dc.contributor.authorS J Park-
dc.contributor.authorS H Lee-
dc.contributor.authorJ H An-
dc.contributor.authorJ W Park-
dc.contributor.authorH Yang-
dc.contributor.authorH Yoon-
dc.contributor.authorJ Bae-
dc.contributor.authorT H Park-
dc.contributor.authorJ Jang-
dc.date.accessioned2017-04-19T10:13:26Z-
dc.date.available2017-04-19T10:13:26Z-
dc.date.issued2015-
dc.identifier.issn1530-6984-
dc.identifier.uri10.1021/acs.nanolett.5b02286ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/12919-
dc.description.abstractHuman sensory-mimicking systems, such as electronic brains, tongues, skin, and ears, have been promoted for use in improving social welfare. However, no significant achievements have been made in mimicking the human nose due to the complexity of olfactory sensory neurons. Combinational coding of human olfactory receptors (hORs) is essential for odorant discrimination in mixtures, and the development of hOR-combined multiplexed systems has progressed slowly. Here, we report the first demonstration of an artificial multiplexed superbioelectronic nose (MSB-nose) that mimics the human olfactory sensory system, leading to high-performance odorant discriminatory ability in mixtures. Specifically, portable MSB-noses were constructed using highly uniform graphene micropatterns (GMs) that were conjugated with two different hORs, which were employed as transducers in a liquid-ion gated field-effect transistor (FET). Field-induced signals from the MSB-nose were monitored and provided high sensitivity and selectivity toward target odorants (minimum detectable level: 0.1 fM). More importantly, the potential of the MSB-nose as a tool to encode hOR combinations was demonstrated using principal component analysis.-
dc.publisherAmer Chem Soc-
dc.titleAn ultrasensitive, selective, multiplexed superbioelectronic nose that mimics the human sense of smell-
dc.title.alternativeAn ultrasensitive, selective, multiplexed superbioelectronic nose that mimics the human sense of smell-
dc.typeArticle-
dc.citation.titleNano Letters-
dc.citation.number10-
dc.citation.endPage6567-
dc.citation.startPage6559-
dc.citation.volume15-
dc.contributor.affiliatedAuthorOh Seok Kwon-
dc.contributor.alternativeName권오석-
dc.contributor.alternativeName송현석-
dc.contributor.alternativeName박선주-
dc.contributor.alternativeName이승환-
dc.contributor.alternativeName안지현-
dc.contributor.alternativeName박진욱-
dc.contributor.alternativeName양희홍-
dc.contributor.alternativeName윤현석-
dc.contributor.alternativeName배준원-
dc.contributor.alternativeName박태현-
dc.contributor.alternativeName장정식-
dc.identifier.bibliographicCitationNano Letters, vol. 15, no. 10, pp. 6559-6567-
dc.identifier.doi10.1021/acs.nanolett.5b02286-
dc.subject.keywordfield-effect transistor-
dc.subject.keywordgraphene micropatterns-
dc.subject.keywordhuman mimicking-
dc.subject.keywordMultiplexed bioelectronic nose-
dc.subject.keywordodorant discrimination-
dc.subject.keywordolfactory receptor-
dc.subject.localField-effect transistor-
dc.subject.localfield-effect transistor-
dc.subject.localgraphene micropatterns-
dc.subject.localhuman mimicking-
dc.subject.localMultiplexed bioelectronic nose-
dc.subject.localodorant discrimination-
dc.subject.localOlfactory receptor-
dc.subject.localolfactory receptor-
dc.description.journalClassY-
Appears in Collections:
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.