Chemical constituents from leaves of Acanthopanax henryi (II)

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Chemical constituents from leaves of Acanthopanax henryi (II)
Z Li; X J Li; Ok-Kyoung Kwon; X Wang; Q P Zou; X Q Liu; Hyeong Kyu Lee
Bibliographic Citation
Natural Products Sciences, vol. 21, no. 3, pp. 196-204
Publication Year
Nineteen compounds, including one organic acid (1), one anthraquinone (2), one amide (3), and sixteen triterpenoid saponins (4 - 19) were isolated from the leaves of Acanthopanax henryi (Oliv.) Harms (Araliaceae). Their structures were determined on the basis of physicochemical properties and spectral analyses (HR-MS and NMR). Among them, compounds 2, 3, 7, 12 and 19 were new within Araliaceae. Compounds 4, 5, 9 - 11, 13, 14, 16 and 18 were reported for the first time from the Acanthopanax genus. Except for compounds 4 and 9, other compounds were isolated from A. henryi (Oliv.) Harms for the first time. The rare anthraquinone, compound 2, significantly decreased the production of NO and the levels of other inflammatory factors, such as TNF-α and IL-6, in lipopolysaccharide (LPS)-stimulated macrophages in a dose-dependent manner. This is the first time to report anti-inflammatory effect of this compound.
Acanthopanax henryiAnthraquinoneAnti-inflammatoryAraliaceaeNitric oxideTriterpenoid saponins
Korean Society of Pharmacognosy
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Ochang Branch Institute > Division of National Bio-Infrastructure > Bio-Resource Central Bank > 1. Journal Articles
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