Haenamindole, an unusual diketopiperazine derivative from a marine-derived Penicillium sp. KCB12F005 = 해양유래사상균 Penicillium sp. KCB12F005로부터 분리한 신규 해남인돌

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Title
Haenamindole, an unusual diketopiperazine derivative from a marine-derived Penicillium sp. KCB12F005 = 해양유래사상균 Penicillium sp. KCB12F005로부터 분리한 신규 해남인돌
Author(s)
Jong Won Kim; Sung-Kyun Ko; Sangkeun Son; Kee Sun ShinIn Ja RyooYoung-Soo Hong; H Oh; B Y Hwang; H Hirota; S Takahashi; Bo Yeon Kim; H Osada; Jae-Hyuk JangJong Seog Ahn
Bibliographic Citation
Bioorganic & Medicinal Chemistry Letters, vol. 25, no. 22, pp. 5398-5401
Publication Year
2015
Abstract
During the chemical investigation of marine-derived fungus, an unusual diketopiperazine (DKP) alkaloid, haenamindole (1), was isolated from a culture of the marine-derived fungus Penicillium sp. KCB12F005. The structure of 1, which possesses benzyl-hydroxypiperazindione and phenyl-pyrimidoindole rings system in the molecule, was elucidated by analysis of NMR and MS data. The stereochemistry of 1 was determined by ROESY and advanced Marfey's method.
Keyword
Diketopiperazine alkaloidMarine-derived fungusPenicillium sp.Pyrimidoindoleβ-Phenylalanine
ISSN
0960-894X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bmcl.2015.09.026
Type
Article
Appears in Collections:
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
Division of Biomaterials Research > Industrial Bio-materials Research Center > 1. Journal Articles
Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
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