Synergistic antiviral activity of gemcitabine and ribavirin against enteroviruses = Gemcitabine과 ribavirin의 상승적 장바이러스 억제효과

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dc.contributor.authorHyunju Kang-
dc.contributor.authorC Kim-
dc.contributor.authorDong-eun Kim-
dc.contributor.authorJae Hyoung Song-
dc.contributor.authorMiri Choi-
dc.contributor.authorKwangman Choi-
dc.contributor.authorMingu Kang-
dc.contributor.authorK Lee-
dc.contributor.authorH S Kim-
dc.contributor.authorJ S Shin-
dc.contributor.authorJanghwan Kim-
dc.contributor.authorS B Han-
dc.contributor.authorM Y Lee-
dc.contributor.authorSu Ui Lee-
dc.contributor.authorC K Lee-
dc.contributor.authorM Kim-
dc.contributor.authorH J Ko-
dc.contributor.authorF J M Kuppeveld-
dc.contributor.authorSungchan Cho-
dc.date.accessioned2017-04-19T10:13:40Z-
dc.date.available2017-04-19T10:13:40Z-
dc.date.issued2015-
dc.identifier.issn0166-3542-
dc.identifier.uri10.1016/j.antiviral.2015.10.011ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/12946-
dc.description.abstractEnteroviruses are major causative agents of various human diseases, and some of them are currently considered to be an enormous threat to public health. However, no effective therapy is currently available for the treatment of these infections. We identified gemcitabine, a nucleoside-analog drug used for cancer treatment, from a screen of bioactive chemicals as a novel inhibitor of coxsackievirus B3 (CVB3) and enterovirus 71 (EV71). Gemcitabine potently inhibited the proliferation of CVB3 and EV71, as well as the replication of CVB3 and EV71 replicons, in cells with a low micromolar IC50 (1-5 μM). Its strong inhibitory effect was also observed in cells infected with human rhinoviruses, demonstrating broad-spectrum antiviral effects on enteroviruses. Mechanistically, an extensive analysis excluded the involvement of 2C, 3A, IRES-dependent translation, and also that of polyprotein processing in the antiviral effects of gemcitabine. Importantly, gemcitabine in combination with ribavirin, an antiviral drug currently being used against a few RNA viruses, exhibited a synergistic antiviral effect on the replication of CVB3 and EV71 replicons. Consequently, our results clearly demonstrate a new indication for gemcitabine as an effective broad-spectrum inhibitor of enteroviruses and strongly suggest a new therapeutic strategy using gemcitabine alone or in combination with ribavirin for the treatment of various diseases associated with enterovirus infection.-
dc.publisherElsevier-
dc.titleSynergistic antiviral activity of gemcitabine and ribavirin against enteroviruses = Gemcitabine과 ribavirin의 상승적 장바이러스 억제효과-
dc.title.alternativeSynergistic antiviral activity of gemcitabine and ribavirin against enteroviruses-
dc.typeArticle-
dc.citation.titleAntiviral Research-
dc.citation.number0-
dc.citation.endPage10-
dc.citation.startPage1-
dc.citation.volume124-
dc.contributor.affiliatedAuthorHyunju Kang-
dc.contributor.affiliatedAuthorDong-eun Kim-
dc.contributor.affiliatedAuthorJae Hyoung Song-
dc.contributor.affiliatedAuthorMiri Choi-
dc.contributor.affiliatedAuthorKwangman Choi-
dc.contributor.affiliatedAuthorMingu Kang-
dc.contributor.affiliatedAuthorJanghwan Kim-
dc.contributor.affiliatedAuthorSu Ui Lee-
dc.contributor.affiliatedAuthorSungchan Cho-
dc.contributor.alternativeName강현주-
dc.contributor.alternativeName김천생-
dc.contributor.alternativeName김동은-
dc.contributor.alternativeName송재형-
dc.contributor.alternativeName최미리-
dc.contributor.alternativeName최광만-
dc.contributor.alternativeName강민구-
dc.contributor.alternativeName이경진-
dc.contributor.alternativeName김해수-
dc.contributor.alternativeName신진수-
dc.contributor.alternativeName김장환-
dc.contributor.alternativeName한상배-
dc.contributor.alternativeName이미영-
dc.contributor.alternativeName이수의-
dc.contributor.alternativeName이종교-
dc.contributor.alternativeName김미현-
dc.contributor.alternativeName고현정-
dc.contributor.alternativeNameKuppeveld-
dc.contributor.alternativeName조성찬-
dc.identifier.bibliographicCitationAntiviral Research, vol. 124, pp. 1-10-
dc.identifier.doi10.1016/j.antiviral.2015.10.011-
dc.subject.keywordAntiviral inhibitor-
dc.subject.keywordEnteroviruses-
dc.subject.keywordGemcitabine-
dc.subject.keywordRibavirin-
dc.subject.localAntiviral inhibitor-
dc.subject.localEnteroviruses-
dc.subject.localenterovirus-
dc.subject.localEnterovirus-
dc.subject.localGemcitabine-
dc.subject.localgemcitabine-
dc.subject.localribavirin-
dc.subject.localRibavirin-
dc.description.journalClassY-
Appears in Collections:
Division of Research on National Challenges > Stem Cell Convergenece Research Center > 1. Journal Articles
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
Ochang Branch Institute > Nucleic Acid Therapeutics Research Center > 1. Journal Articles
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