Sulfuretin induces osteoblast differentiation through activation of TGF-β signaling = TGF베타 신호전달체계를 통한 설퓨레틴의 조골세포 분화 촉진

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dc.contributor.authorN J Song-
dc.contributor.authorS M Kwon-
dc.contributor.authorS Kim-
dc.contributor.authorH J Yoon-
dc.contributor.authorC R Seo-
dc.contributor.authorB Jang-
dc.contributor.authorS H Chang-
dc.contributor.authorJ M Ku-
dc.contributor.authorJeong Soo Lee-
dc.contributor.authorK M Park-
dc.contributor.authorJ W Hong-
dc.contributor.authorG H Kim-
dc.contributor.authorK W Park-
dc.date.accessioned2017-04-19T10:13:54Z-
dc.date.available2017-04-19T10:13:54Z-
dc.date.issued2015-
dc.identifier.issn03008177-
dc.identifier.uri10.1007/s11010-015-2537-5ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/12952-
dc.description.abstractThe identification and examination of potential determinants controlling the progression of cell fate toward osteoblasts can be intriguing subjects. In this study, the effects of sulfuretin, a major compound isolated from Rhus verniciflua Stokes, on osteoblast differentiation were investigated. Treatments of sulfuretin induced alkaline phosphatase (ALP) activity in mesenchymal C3H10T1/2 cells and mineralization in preosteoblast MC3T3-E1 cells. Pro-osteogenic effects of sulfuretin were consistently observed in freshly isolated primary bone marrow cells. In mechanical studies, sulfuretin specifically induced expression of TGF-β target genes, such as SMAD7 and PAI-1, but not other signaling pathway-related genes. Similar to the results of gene expression analysis, reporter assays further demonstrated TGF-β-specific induction by sulfuretin. Furthermore, disruption of TGF-β signaling using treatment with TGF-β-specific inhibitor, SB-431542, and introduction of SMAD2/3 small interfering RNA impaired the effects of sulfuretin in inducing ALP activity and expression of ALP mRNA. Together, these data indicate that the pro-osteogenic effects of sulfuretin are mediated through activation of TGF-β signaling, further supporting the potential of sulfuretin in the prevention of bone-related diseases such as bone fracture and osteoporosis.-
dc.publisherSpringer-
dc.titleSulfuretin induces osteoblast differentiation through activation of TGF-β signaling = TGF베타 신호전달체계를 통한 설퓨레틴의 조골세포 분화 촉진-
dc.title.alternativeSulfuretin induces osteoblast differentiation through activation of TGF-β signaling-
dc.typeArticle-
dc.citation.titleMolecular and Cellular Biochemistry-
dc.citation.number1-
dc.citation.endPage63-
dc.citation.startPage55-
dc.citation.volume410-
dc.contributor.affiliatedAuthorJeong Soo Lee-
dc.contributor.alternativeName송노준-
dc.contributor.alternativeName권소미-
dc.contributor.alternativeName김수지-
dc.contributor.alternativeName윤향진-
dc.contributor.alternativeName서초롱-
dc.contributor.alternativeName장병현-
dc.contributor.alternativeName장세혁-
dc.contributor.alternativeName구진모-
dc.contributor.alternativeName이정수-
dc.contributor.alternativeName박기문-
dc.contributor.alternativeName홍정우-
dc.contributor.alternativeName김근형-
dc.contributor.alternativeName박계원-
dc.identifier.bibliographicCitationMolecular and Cellular Biochemistry, vol. 410, no. 1, pp. 55-63-
dc.identifier.doi10.1007/s11010-015-2537-5-
dc.subject.keywordC3H10T1/2 cells-
dc.subject.keywordMC3T3-E1 cells-
dc.subject.keywordOsteoblast differentiation-
dc.subject.keywordSulfuretin-
dc.subject.keywordTGF-beta-
dc.subject.localC3H10T1/2 cells-
dc.subject.localMC3T3-E1 cells-
dc.subject.localOsteoblast differentiation-
dc.subject.localSulfuretin-
dc.subject.localTGF-beta-
dc.subject.localTGF-β-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Disease Target Structure Research Center > 1. Journal Articles
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