Therapeutic implications for overcoming radiation resistance in cancer therapy

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Title
Therapeutic implications for overcoming radiation resistance in cancer therapy
Author(s)
B M Kim; Y Hong; S Lee; P Liu; J H Lim; Y H Lee; T H Lee; Kyu Tae Chang; Y Hong
Bibliographic Citation
International Journal of Molecular Sciences, vol. 16, no. 11, pp. 26880-26913
Publication Year
2015
Abstract
Ionizing radiation (IR), such as X-rays and gamma (γ)-rays, mediates various forms of cancer cell death such as apoptosis, necrosis, autophagy, mitotic catastrophe, and senescence. Among them, apoptosis and mitotic catastrophe are the main mechanisms of IR action. DNA damage and genomic instability contribute to IR-induced cancer cell death. Although IR therapy may be curative in a number of cancer types, the resistance of cancer cells to radiation remains a major therapeutic problem. In this review, we describe the morphological and molecular aspects of various IR-induced types of cell death. We also discuss cytogenetic variations representative of IR-induced DNA damage and genomic instability. Most importantly, we focus on several pathways and their associated marker proteins responsible for cancer resistance and its therapeutic implications in terms of cancer cell death of various types and characteristics. Finally, we propose radiation-sensitization strategies, such as the modification of fractionation, inflammation, and hypoxia and the combined treatment, that can counteract the resistance of tumors to IR.
Keyword
Cancer therapyCell deathDNA damageIonizing radiation (IR)Prognostic markersResistanceTherapeutic targets
ISSN
1422-0067
Publisher
MDPI
DOI
http://dx.doi.org/10.3390/ijms161125991
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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