NFATc1 regulates the transcription of DNA damage-induced apoptosis suppressor

Cited 4 time in scopus
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Title
NFATc1 regulates the transcription of DNA damage-induced apoptosis suppressor
Author(s)
Joo-Young Im; K W Lee; Kyoung Jae Won; Bo Kyung KimHyun Seung Ban; Sung Hoon Yoon; Young-Ju Lee; Young Joo Kim; K B Song; Mi Sun Won
Bibliographic Citation
Data in Brief, vol. 5, pp. 975-980
Publication Year
2015
Abstract
DNA damage induced apoptosis suppressor (DDIAS), or human Noxin (hNoxin), is strongly expressed in lung cancers. DDIAS knockdown induced apoptosis in non-small cell lung carcinoma A549 cells in response to DNA damage, indicating DDIAS as a potential therapeutic target in lung cancer. To understand the transcriptional regulation of DDIAS, we determined the transcription start site, promoter region, and transcription factor. We found that DDIAS transcription begins at nucleotide 212 upstream of the DDIAS translation start site. We cloned the DDIAS promoter region and identified NFAT2 as a major transcription factor (Im et al., 2016 [1]). We demonstrated that NFATc1 regulates DDIAS expression in both pancreatic cancer Panc-1 cells and lung cancer cells.
Keyword
ChIPDDIASLung cancerNFATc1Pancreatic cancer
ISSN
2352-3409
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.dib.2015.11.011
Type
Article
Appears in Collections:
Division of Biomedical Research > Personalized Genomic Medicine Research Center > 1. Journal Articles
Division of Biomedical Research > Biotherapeutics Translational Research Center > 1. Journal Articles
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