DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jae Min Yoo | - |
dc.contributor.author | Y W Park | - |
dc.contributor.author | S Y Yoon | - |
dc.contributor.author | J Y Son | - |
dc.contributor.author | S G Jeong | - |
dc.contributor.author | B Y Park | - |
dc.contributor.author | Jae Wha Kim | - |
dc.contributor.author | M S Nam | - |
dc.date.accessioned | 2017-04-19T10:16:11Z | - |
dc.date.available | 2017-04-19T10:16:11Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0021-8561 | - |
dc.identifier.uri | 10.1021/acs.jafc.5b04790. | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/13058 | - |
dc.description.abstract | α-Lactalbumin and β-lactoglobulin are two major whey proteins that specifically bind immunoglobulin E and are suspected as major allergens causing cow's milk allergy (CMA). Recent studies have shown that thymic stromal lymphopoietin is a critical factor linking at the interface of the body and environment to the T-helper 2 response. However, it is not known whether thymic stromal lymphopoietin expression is changed by α-lactalbumin and β-lactoglobulin in immune cells. Using RT-PCR and ELISA, the present study was conducted to examine if intravenous injection of α-lactalbumin and β-lactoglobulin increased pro-inflammatory cytokines, T-helper 2 cytokines, and thymic stromal lymphopoietin expression in several immune cells, including macrophages, mast cells, and keratinocytes. Results showed that α-lactalbumin and β-lactoglobulin induced thymic stromal lymphopoietin, interleukin-6, and tumor necrosis factor-α expression. It was concluded that the allergenicity of α-lactalbumin and β-lactoglobulin may be attributed to thymic stromal lymphopoietin induction, T-helper 2 cytokines, and pro-inflammatory cytokines. | - |
dc.publisher | Amer Chem Soc | - |
dc.title | Thymic stromal lymphopoietin induction is mediated by the major whey proteins α-lactalbumin and β-lactoglobulin through the NF-κB pathway in immune cells | - |
dc.title.alternative | Thymic stromal lymphopoietin induction is mediated by the major whey proteins α-lactalbumin and β-lactoglobulin through the NF-κB pathway in immune cells | - |
dc.type | Article | - |
dc.citation.title | Journal of Agricultural and Food Chemistry | - |
dc.citation.number | 50 | - |
dc.citation.endPage | 10810 | - |
dc.citation.startPage | 10803 | - |
dc.citation.volume | 63 | - |
dc.contributor.affiliatedAuthor | Jae Min Yoo | - |
dc.contributor.affiliatedAuthor | Jae Wha Kim | - |
dc.contributor.alternativeName | 유재민 | - |
dc.contributor.alternativeName | 박영우 | - |
dc.contributor.alternativeName | 윤선영 | - |
dc.contributor.alternativeName | 손지윤 | - |
dc.contributor.alternativeName | 정석근 | - |
dc.contributor.alternativeName | 박범영 | - |
dc.contributor.alternativeName | 김재화 | - |
dc.contributor.alternativeName | 남명수 | - |
dc.identifier.bibliographicCitation | Journal of Agricultural and Food Chemistry, vol. 63, no. 50, pp. 10803-10810 | - |
dc.identifier.doi | 10.1021/acs.jafc.5b04790 | - |
dc.subject.keyword | pro-inflammatory cytokine | - |
dc.subject.keyword | T-helper 2 cytokine | - |
dc.subject.keyword | thymic stromal lymphopoietin | - |
dc.subject.keyword | α-lactalbumin | - |
dc.subject.keyword | β-lactoglobulin | - |
dc.subject.local | Pro-inflammatory cytokine | - |
dc.subject.local | Pro-inflammatory cytokines | - |
dc.subject.local | Proinflammatory cytokine | - |
dc.subject.local | Proinflammatory cytokines | - |
dc.subject.local | pro-inflammatory cytokine | - |
dc.subject.local | proinflammatory cytokine | - |
dc.subject.local | T-helper 2 cytokine | - |
dc.subject.local | thymic stromal lymphopoietin | - |
dc.subject.local | Thymic stromal lymphopoietin (TSLP) | - |
dc.subject.local | α-lactalbumin | - |
dc.subject.local | β-lactoglobulin | - |
dc.description.journalClass | Y | - |
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