Thymic stromal lymphopoietin induction is mediated by the major whey proteins α-lactalbumin and β-lactoglobulin through the NF-κB pathway in immune cells

Cited 4 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorJae Min Yoo-
dc.contributor.authorY W Park-
dc.contributor.authorS Y Yoon-
dc.contributor.authorJ Y Son-
dc.contributor.authorS G Jeong-
dc.contributor.authorB Y Park-
dc.contributor.authorJae Wha Kim-
dc.contributor.authorM S Nam-
dc.date.accessioned2017-04-19T10:16:11Z-
dc.date.available2017-04-19T10:16:11Z-
dc.date.issued2015-
dc.identifier.issn0021-8561-
dc.identifier.uri10.1021/acs.jafc.5b04790.ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/13058-
dc.description.abstractα-Lactalbumin and β-lactoglobulin are two major whey proteins that specifically bind immunoglobulin E and are suspected as major allergens causing cow's milk allergy (CMA). Recent studies have shown that thymic stromal lymphopoietin is a critical factor linking at the interface of the body and environment to the T-helper 2 response. However, it is not known whether thymic stromal lymphopoietin expression is changed by α-lactalbumin and β-lactoglobulin in immune cells. Using RT-PCR and ELISA, the present study was conducted to examine if intravenous injection of α-lactalbumin and β-lactoglobulin increased pro-inflammatory cytokines, T-helper 2 cytokines, and thymic stromal lymphopoietin expression in several immune cells, including macrophages, mast cells, and keratinocytes. Results showed that α-lactalbumin and β-lactoglobulin induced thymic stromal lymphopoietin, interleukin-6, and tumor necrosis factor-α expression. It was concluded that the allergenicity of α-lactalbumin and β-lactoglobulin may be attributed to thymic stromal lymphopoietin induction, T-helper 2 cytokines, and pro-inflammatory cytokines.-
dc.publisherAmer Chem Soc-
dc.titleThymic stromal lymphopoietin induction is mediated by the major whey proteins α-lactalbumin and β-lactoglobulin through the NF-κB pathway in immune cells-
dc.title.alternativeThymic stromal lymphopoietin induction is mediated by the major whey proteins α-lactalbumin and β-lactoglobulin through the NF-κB pathway in immune cells-
dc.typeArticle-
dc.citation.titleJournal of Agricultural and Food Chemistry-
dc.citation.number50-
dc.citation.endPage10810-
dc.citation.startPage10803-
dc.citation.volume63-
dc.contributor.affiliatedAuthorJae Min Yoo-
dc.contributor.affiliatedAuthorJae Wha Kim-
dc.contributor.alternativeName유재민-
dc.contributor.alternativeName박영우-
dc.contributor.alternativeName윤선영-
dc.contributor.alternativeName손지윤-
dc.contributor.alternativeName정석근-
dc.contributor.alternativeName박범영-
dc.contributor.alternativeName김재화-
dc.contributor.alternativeName남명수-
dc.identifier.bibliographicCitationJournal of Agricultural and Food Chemistry, vol. 63, no. 50, pp. 10803-10810-
dc.identifier.doi10.1021/acs.jafc.5b04790-
dc.subject.keywordpro-inflammatory cytokine-
dc.subject.keywordT-helper 2 cytokine-
dc.subject.keywordthymic stromal lymphopoietin-
dc.subject.keywordα-lactalbumin-
dc.subject.keywordβ-lactoglobulin-
dc.subject.localPro-inflammatory cytokine-
dc.subject.localPro-inflammatory cytokines-
dc.subject.localProinflammatory cytokine-
dc.subject.localProinflammatory cytokines-
dc.subject.localpro-inflammatory cytokine-
dc.subject.localproinflammatory cytokine-
dc.subject.localT-helper 2 cytokine-
dc.subject.localthymic stromal lymphopoietin-
dc.subject.localThymic stromal lymphopoietin (TSLP)-
dc.subject.localα-lactalbumin-
dc.subject.localβ-lactoglobulin-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.