Black phosphorus (BP) nanodots for potential biomedical applications

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Title
Black phosphorus (BP) nanodots for potential biomedical applications
Author(s)
H U Lee; S Y Park; S C Lee; Saehae Choi; S Seo; H Kim; J Won; K Choi; K S Kang; H G Park; Hee-Sik Kim; H R An; K H Jeong; Y C Lee; J Lee
Bibliographic Citation
Small, vol. 12, no. 2, pp. 214-219
Publication Year
2016
Abstract
Recently, the appeal of 2D black phosphorus (BP) has been rising due to its unique optical and electronic properties with a tunable band gap (?0.3-1.5 eV). While numerous research efforts have recently been devoted to nano- and optoelectronic applications of BP, no attention has been paid to promising medical applications. In this article, the preparation of BP-nanodots of a few nm to <20 nm with an average diameter of ?10 nm and height of ?8.7 nm is reported by a modified ultrasonication-assisted solution method. Stable formation of nontoxic phosphates and phosphonates from BP crystals with exposure in water or air is observed. As for the BP-nanodot crystals' stability (ionization and persistence of fluorescent intensity) in aqueous solution, after 10 d, ?80% at 1.5 mg mL-1 are degraded (i.e., ionized) in phosphate buffered saline. They showed no or little cytotoxic cell-viability effects in vitro involving blue- and green-fluorescence cell imaging. Thus, BP-nanodots can be considered a promising agent for drug delivery or cellular tracking systems.
Keyword
black phosphoruscell imagingcytotoxicitymedical applicationsnanodots
ISSN
1613-6810
Publisher
Wiley
DOI
http://dx.doi.org/10.1002/smll.201502756
Type
Article
Appears in Collections:
Division of Biomaterials Research > Cell Factory Research Center > 1. Journal Articles
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