Streptomyces-derived actinomycin D inhibits biofilm formation by Staphylococcus aureus and its hemolytic activity

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dc.contributor.authorJ H Lee-
dc.contributor.authorY G Kim-
dc.contributor.authorK Lee-
dc.contributor.authorChang-Jin Kim-
dc.contributor.authorDong Jin Park-
dc.contributor.authorYoonjung Ju-
dc.contributor.authorJ C Lee-
dc.contributor.authorT K Wood-
dc.contributor.authorJ Lee-
dc.date.accessioned2017-04-19T10:16:35Z-
dc.date.available2017-04-19T10:16:35Z-
dc.date.issued2016-
dc.identifier.issn08927014-
dc.identifier.uri10.1080/08927014.2015.1125888ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/13094-
dc.description.abstractStaphylococcus aureus is a versatile human pathogen that produces diverse virulence factors, and its biofilm cells are difficult to eradicate due to their inherent ability to tolerate antibiotics. The anti-biofilm activities of the spent media of 252 diverse endophytic microorganisms were investigated using three S. aureus strains. An attempt was made to identify anti-biofilm compounds in active spent media and to assess their anti-hemolytic activities and hydrophobicities in order to investigate action mechanisms. Unlike other antibiotics, actinomycin D (0.5 μg ml?1) from Streptomyces parvulus significantly inhibited biofilm formation by all three S. aureus strains. Actinomycin D inhibited slime production in S. aureus and it inhibited hemolysis by S. aureus and caused S. aureus cells to become less hydrophobic, thus supporting its anti-biofilm effect. In addition, surface coatings containing actinomycin D prevented S. aureus biofilm formation on glass surfaces. Given these results, FDA-approved actinomycin D warrants further attention as a potential antivirulence agent against S. aureus infections.-
dc.publisherT&F (Taylor & Francis)-
dc.titleStreptomyces-derived actinomycin D inhibits biofilm formation by Staphylococcus aureus and its hemolytic activity-
dc.title.alternativeStreptomyces-derived actinomycin D inhibits biofilm formation by Staphylococcus aureus and its hemolytic activity-
dc.typeArticle-
dc.citation.titleBiofouling-
dc.citation.number1-
dc.citation.endPage56-
dc.citation.startPage45-
dc.citation.volume32-
dc.contributor.affiliatedAuthorChang-Jin Kim-
dc.contributor.affiliatedAuthorDong Jin Park-
dc.contributor.affiliatedAuthorYoonjung Ju-
dc.contributor.alternativeName이진형-
dc.contributor.alternativeName김용규-
dc.contributor.alternativeName이가연-
dc.contributor.alternativeName김창진-
dc.contributor.alternativeName박동진-
dc.contributor.alternativeName주윤정-
dc.contributor.alternativeName이재찬-
dc.contributor.alternativeNameWood-
dc.contributor.alternativeName이진태-
dc.identifier.bibliographicCitationBiofouling, vol. 32, no. 1, pp. 45-56-
dc.identifier.doi10.1080/08927014.2015.1125888-
dc.subject.keywordActinomycin D-
dc.subject.keywordbiofilm-
dc.subject.keywordhemolysis-
dc.subject.keywordhydrophobicity-
dc.subject.keywordStaphylococcus aureus-
dc.subject.localActinomycin D-
dc.subject.localbiofilm-
dc.subject.localBiofilm-
dc.subject.localhemolysis-
dc.subject.localhydrophobicity-
dc.subject.localHydrophobicity-
dc.subject.localStaphylococcus aureus-
dc.description.journalClassY-
Appears in Collections:
Division of Biomaterials Research > Industrial Bio-materials Research Center > 1. Journal Articles
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