DC Field | Value | Language |
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dc.contributor.author | J H Lee | - |
dc.contributor.author | Y G Kim | - |
dc.contributor.author | K Lee | - |
dc.contributor.author | Chang-Jin Kim | - |
dc.contributor.author | Dong Jin Park | - |
dc.contributor.author | Yoonjung Ju | - |
dc.contributor.author | J C Lee | - |
dc.contributor.author | T K Wood | - |
dc.contributor.author | J Lee | - |
dc.date.accessioned | 2017-04-19T10:16:35Z | - |
dc.date.available | 2017-04-19T10:16:35Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0892-7014 | - |
dc.identifier.uri | 10.1080/08927014.2015.1125888 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/13094 | - |
dc.description.abstract | Staphylococcus aureus is a versatile human pathogen that produces diverse virulence factors, and its biofilm cells are difficult to eradicate due to their inherent ability to tolerate antibiotics. The anti-biofilm activities of the spent media of 252 diverse endophytic microorganisms were investigated using three S. aureus strains. An attempt was made to identify anti-biofilm compounds in active spent media and to assess their anti-hemolytic activities and hydrophobicities in order to investigate action mechanisms. Unlike other antibiotics, actinomycin D (0.5 μg ml?1) from Streptomyces parvulus significantly inhibited biofilm formation by all three S. aureus strains. Actinomycin D inhibited slime production in S. aureus and it inhibited hemolysis by S. aureus and caused S. aureus cells to become less hydrophobic, thus supporting its anti-biofilm effect. In addition, surface coatings containing actinomycin D prevented S. aureus biofilm formation on glass surfaces. Given these results, FDA-approved actinomycin D warrants further attention as a potential antivirulence agent against S. aureus infections. | - |
dc.publisher | T&F (Taylor & Francis) | - |
dc.title | Streptomyces-derived actinomycin D inhibits biofilm formation by Staphylococcus aureus and its hemolytic activity | - |
dc.title.alternative | Streptomyces-derived actinomycin D inhibits biofilm formation by Staphylococcus aureus and its hemolytic activity | - |
dc.type | Article | - |
dc.citation.title | Biofouling | - |
dc.citation.number | 1 | - |
dc.citation.endPage | 56 | - |
dc.citation.startPage | 45 | - |
dc.citation.volume | 32 | - |
dc.contributor.affiliatedAuthor | Chang-Jin Kim | - |
dc.contributor.affiliatedAuthor | Dong Jin Park | - |
dc.contributor.affiliatedAuthor | Yoonjung Ju | - |
dc.contributor.alternativeName | 이진형 | - |
dc.contributor.alternativeName | 김용규 | - |
dc.contributor.alternativeName | 이가연 | - |
dc.contributor.alternativeName | 김창진 | - |
dc.contributor.alternativeName | 박동진 | - |
dc.contributor.alternativeName | 주윤정 | - |
dc.contributor.alternativeName | 이재찬 | - |
dc.contributor.alternativeName | Wood | - |
dc.contributor.alternativeName | 이진태 | - |
dc.identifier.bibliographicCitation | Biofouling, vol. 32, no. 1, pp. 45-56 | - |
dc.identifier.doi | 10.1080/08927014.2015.1125888 | - |
dc.subject.keyword | Actinomycin D | - |
dc.subject.keyword | biofilm | - |
dc.subject.keyword | hemolysis | - |
dc.subject.keyword | hydrophobicity | - |
dc.subject.keyword | Staphylococcus aureus | - |
dc.subject.local | Actinomycin D | - |
dc.subject.local | Biofilm | - |
dc.subject.local | Biofilms | - |
dc.subject.local | biofilm | - |
dc.subject.local | biofilms | - |
dc.subject.local | hemolysis | - |
dc.subject.local | Hydrophobicity | - |
dc.subject.local | hydrophobicity | - |
dc.subject.local | Staphylococcus aureus | - |
dc.subject.local | staphylococcus aureus | - |
dc.description.journalClass | Y | - |
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