Open Access@KRIBBDivision of A.I. & Biomedical ResearchMetabolic Regulation Research Center1. Journal Articles
Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 4 (vIRF4) perturbs the G1-S cell cycle progression via deregulation of the cyclin D1 gene
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- Title
- Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 4 (vIRF4) perturbs the G1-S cell cycle progression via deregulation of the cyclin D1 gene
- Author(s)
- H R Lee; J Mitra; S Lee; S J Gao; Tae Kwang Oh; Myung Hee Kim; T Ha; J U Jung
- Bibliographic Citation
- Journal of Virology, vol. 90, no. 2, pp. 1139-1143
- Publication Year
- 2016
- Abstract
- Kaposi's sarcoma-associated herpesvirus (KSHV) infection modulates the host cell cycle to create an environment optimal for its viral-DNA replication during the lytic life cycle. We report here that KSHV vIRF4 targets the β-catenin/CBP cofactor and blocks its occupancy on the cyclin D1 promoter, suppressing the G1-S cell cycle progression and enhancing KSHV replication. This shows that KSHV vIRF4 suppresses host G1-S transition, possibly providing an intracellular milieu favorable for its replication.
- ISSN
- 0022-538X
- Publisher
- Amer Soc Microb
- Full Text Link
- http://dx.doi.org/10.1128/JVI.01897-15
- Type
- Article
- Appears in Collections:
- Division of A.I. & Biomedical Research > Metabolic Regulation Research Center > 1. Journal Articles
Division of A.I. & Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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