Penidioxolanes A and B, 1,3-dioxolane containing azaphilone derivatives from marine-derived Penicillium sp. KCB12C078

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Title
Penidioxolanes A and B, 1,3-dioxolane containing azaphilone derivatives from marine-derived Penicillium sp. KCB12C078
Author(s)
Seung Min Kim; Sangkeun Son; Jong Won Kim; Eun Soo Jeon; Sung-Kyun KoIn Ja RyooKee Sun Shin; H Hirota; S Takahashi; H Osada; Jae-Hyuk JangJong Seog Ahn
Bibliographic Citation
Natural Products Sciences, vol. 21, no. 4, pp. 231-236
Publication Year
2015
Abstract
Two new azaphilone derivatives containing 1,3-dioxolane moiety, penidioxolanes A (1) and B (2), were isolated from marine-derived fungus Penicillium sp. KCB12C078, together with four known compounds (3-6) by chemical investigation. Compounds 1 - 6 were isolated by combination of silica gel, ODS column chromatography and preparative HPLC. Their structures were determined by analysis of spectroscopic data including 1D-, 2D-NMR, and MS techniques. The isolates were evaluated against cancer cell growth inhibition effects and antimicrobial activity.
Keyword
1,3-DioxolaneAzaphilone derivativesMarine-derived fungusPenicillium
ISSN
I000-0147
Publisher
Korean Society of Pharmacognosy
DOI
http://dx.doi.org/10.20307/nps.2015.21.4.231
Type
Article
Appears in Collections:
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
Division of Biomaterials Research > Industrial Bio-materials Research Center > 1. Journal Articles
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