A metabolomics approach to identify factors influencing their activity relative to oleanolic acid contents in Korean mistletoe types

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Title
A metabolomics approach to identify factors influencing their activity relative to oleanolic acid contents in Korean mistletoe types
Author(s)
H H Song; Hyung Won Ryu; Hui Seong Kim; C S Kim; H J Hyun; Hyeong Kyu Lee; Sei-Ryang Oh
Bibliographic Citation
Journal of Functional Foods, vol. 22, pp. 64-72
Publication Year
2016
Abstract
The metabolite changes in Korean mistletoe, as functional food, and their effects on its biological activity were monitored. The Korean mistletoe species were successfully distinguished by hierarchical clustering analysis (HCA) in atmospheric-pressure chemical ionization (APCI) and electrospray ionization (ESI) mode. As shown by the PCA scatter plot and loading plot, the Santalaceae family exhibited significant markers derived from oleanolic acid, whereas the Loranthaceae family exhibited tentative markers derived from glycosidic derivatives of quercetin and kaempferol. The mistletoe extracts also inhibited plasminogen activator inhibitor 1 (PAI-1) differently depending on the mistletoe family. The Santalaceae family was shown to be a potent inhibitor of PAI-1, with an IC50 value of around 40.0 μg/mL. In contrast, the Loranthaceae family extracts did not inhibit PAI-1. Importantly, discrimination was shown across the chemotaxonomy of the plant, which correlated strongly with the oleanolic acid contents in Korean mistletoe.
Keyword
ChemotaxonomyGlyconeKorean mistletoeOleanolic acidOleanolic acid (PubChem CID: 10494)Peltatoside (PubChem CID: 5484066)Plasminogen activator inhibitor-1Rhamnetin-3-O-rhamnoside (PubChem CID: 5491382)Vicenin-2 (PubChem CID: 442664)
ISSN
1756-4646
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.jff.2016.01.007
Type
Article
Appears in Collections:
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
Ochang Branch Institute > 1. Journal Articles
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