Biosynthesis of novel glucosides geldanamycin analogs by enzymatic synthesis

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dc.contributor.authorQ Huo-
dc.contributor.authorH M Li-
dc.contributor.authorJae Kyoung Lee-
dc.contributor.authorJ Li-
dc.contributor.authorT Ma-
dc.contributor.authorX Zhang-
dc.contributor.authorY Dai-
dc.contributor.authorYoung-Soo Hong-
dc.contributor.authorC Z Wu-
dc.date.accessioned2017-04-19T10:17:17Z-
dc.date.available2017-04-19T10:17:17Z-
dc.date.issued2016-
dc.identifier.issn10177825-
dc.identifier.uri10.4014/jmb.1508.08069ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/13132-
dc.description.abstractTwo new glucosides (1 and 2) of geldanamycin (GA) analogs were obtained from in vitro glycosylation by UDP-glycosyltransferase (YjiC). Based on spectroscopic (HR-ESI-MS, 1D, and 2D-NMR) analyses, the glucosides were elucidated as 4,5-dihydro-7-O-descarbamoyl-7- hydroxyl GA-7-O-β-D-glucoside (1) and ACDL3172-18-O-β-D-glucoside (2). Furthermore, the water solubility of compounds 1 and 2 was about 215.2 and 90.7 times higher respectively, than that of the substrates. Among compounds 1-4, only 3 showed weak antiproliferative activity against four human tumor cell lines: MDA-MB-231, SMMC7721, HepG2, and SW480 (IC50: 13.6, 15.1, 31.8, and 22.7 μM, respectively).-
dc.publisherSouth Korea-
dc.titleBiosynthesis of novel glucosides geldanamycin analogs by enzymatic synthesis-
dc.title.alternativeBiosynthesis of novel glucosides geldanamycin analogs by enzymatic synthesis-
dc.typeArticle-
dc.citation.titleJournal of Microbiology and Biotechnology-
dc.citation.number1-
dc.citation.endPage60-
dc.citation.startPage56-
dc.citation.volume26-
dc.contributor.affiliatedAuthorYoung-Soo Hong-
dc.contributor.alternativeNameHuo-
dc.contributor.alternativeNameLi-
dc.contributor.alternativeName이재경-
dc.contributor.alternativeNameLi-
dc.contributor.alternativeNameMa-
dc.contributor.alternativeNameZhang-
dc.contributor.alternativeNameDai-
dc.contributor.alternativeName홍영수-
dc.contributor.alternativeNameWu-
dc.identifier.bibliographicCitationJournal of Microbiology and Biotechnology, vol. 26, no. 1, pp. 56-60-
dc.identifier.doi10.4014/jmb.1508.08069-
dc.subject.keywordCytotoxicity-
dc.subject.keywordGeldanamycin analogs-
dc.subject.keywordGlycosyltransferase-
dc.subject.keywordWater solubility-
dc.subject.localCytotoxicity-
dc.subject.localGeldanamycin analogs-
dc.subject.localGlycosyltransferase-
dc.subject.localWater solubility-
dc.description.journalClassY-
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Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
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