Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2011-2015)

Cited 37 time in scopus
Metadata Downloads
Title
Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2011-2015)
Author(s)
Hyun Seung Ban; Y Uto; Mi Sun Won; H Nakamura
Bibliographic Citation
Expert Opinion on Therapeutic Patents, vol. 26, no. 3, pp. 309-322
Publication Year
2016
Abstract
Introduction: Hypoxia-inducible factor (HIF)-1α regulates the expression of genes involved in angiogenesis, cellular energy metabolism, and cell survival during cancer development. The increased expression of HIF-1α in most solid tumors is associated with poor prognoses and therapeutic outcomes. Therefore, HIF has been recognized as an attractive target for cancer therapy, and many HIF inhibitors have been reported. Areas covered: This patent survey summarizes the information about patented HIF inhibitors over the last 5 years (2011-2015). Expert opinion: Although many of the HIF inhibitors reviewed in this patent survey possess inhibitory activity against cancer and HIF-related diseases, the compounds are still in the early stages of development, most likely due to the complexity of the HIF-1 pathway and their different mechanisms of action for HIF inhibition. Most cancer cells use the glycolytic pathway for energy production and HIF-1α participates deeply in the expression of several glycolytic enzymes. Therefore, a detailed study of HIFs function in cancer metabolisms may provide us an alternative strategy for further development of HIF inhibitors in cancer therapy.
Keyword
cancerCarcinogenesisHIF inhibitorshypoxiahypoxia-inducible factor (HIF)
ISSN
1354-3776
Publisher
T&F (Taylor & Francis)
DOI
http://dx.doi.org/10.1517/13543776.2016.1146252
Type
Article
Appears in Collections:
Division of Biomedical Research > Biotherapeutics Translational Research Center > 1. Journal Articles
Division of Biomedical Research > Personalized Genomic Medicine Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.