High-performance dendritic contrast agents for X-ray computed tomography imaging using potent tetraiodobenzene derivatives

Cited 31 time in scopus
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Title
High-performance dendritic contrast agents for X-ray computed tomography imaging using potent tetraiodobenzene derivatives
Author(s)
Suyeon You; Hye-youn Jung; Chaewoon Lee; Yun Hui Choe; Ju Young Heo; Gil Tae Gang; Sang-Kyung Byun; Won Kon KimChul Ho Lee; D E Kim; Y I Kim; Yoonkyung Kim
Bibliographic Citation
Journal of Controlled Release, vol. 226, pp. 258-267
Publication Year
2016
Abstract
The use of computed tomography (CT) for vascular imaging is critical in medical emergencies requiring urgent diagnostic decisions, such as cerebral ischemia and many cardiovascular diseases. Small-molecule iodinated contrast media are often injected intravenously as radiopaque agents during CT imaging to achieve high contrast enhancement of vascular systems. The rapid excretion rate of these agents is overcome by injecting a significantly high dose of iodine, which can have serious side effects. Here we report a simple method to prepare blood-pool contrast agents for CT based on dendrimers for the first time using tetraiodobenzene derivatives as potent radiopaque moieties. Excellent in vivo safety has been demonstrated for these small (13-22nm) unimolecular water-soluble dendritic contrast agents, which exhibit high contrast enhancement in the blood-pool and effectively extend their blood half-lives. Our method is applicable to virtually any scaffold with suitable surface groups and may fulfill the current need for safer, next-generation iodinated CT contrast agents.
Keyword
DendrimersComputed tomographyIn vivo imagingIodinated contrast agentsNanomedicine
ISSN
0168-3659
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.jconrel.2016.01.036
Type
Article
Appears in Collections:
Division of Biomedical Research > Metabolic Regulation Research Center > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
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