Structure-activity relationship study of a series of novel oxazolidinone derivatives as IL-6 signaling blockers
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | S Singh | - |
| dc.contributor.author | V Gajulapati | - |
| dc.contributor.author | K Gajulapati | - |
| dc.contributor.author | J I Goo | - |
| dc.contributor.author | Y H Park | - |
| dc.contributor.author | H Y Jung | - |
| dc.contributor.author | S Y Lee | - |
| dc.contributor.author | Jeong Ho Choi | - |
| dc.contributor.author | Young-Kook Kim | - |
| dc.contributor.author | K Lee | - |
| dc.contributor.author | T H Heo | - |
| dc.contributor.author | Y Choi | - |
| dc.date.accessioned | 2017-04-19T10:18:17Z | - |
| dc.date.available | 2017-04-19T10:18:17Z | - |
| dc.date.issued | 2016 | - |
| dc.identifier.issn | 0960-894X | - |
| dc.identifier.uri | 10.1016/j.bmcl.2016.01.016 | ko |
| dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/13157 | - |
| dc.description.abstract | A series of oxazolidinone and indole derivatives were synthesized and evaluated as IL-6 signaling blockers by measuring the effects of these compounds on IL-6-induced luciferase expression in human hepatocarcinoma HepG2 cells transfected with p-STAT3-Luc. Among different compounds screened, compound 4d was emerged as the most potent IL-6 signaling blockers with IC50 value of 5.9 μM which was much better than (+)-Madindoline A (IC50 = 21 μM), a known inhibitor of IL-6. | - |
| dc.publisher | Elsevier | - |
| dc.title | Structure-activity relationship study of a series of novel oxazolidinone derivatives as IL-6 signaling blockers | - |
| dc.title.alternative | Structure-activity relationship study of a series of novel oxazolidinone derivatives as IL-6 signaling blockers | - |
| dc.type | Article | - |
| dc.citation.title | Bioorganic & Medicinal Chemistry Letters | - |
| dc.citation.number | 4 | - |
| dc.citation.endPage | 1286 | - |
| dc.citation.startPage | 1282 | - |
| dc.citation.volume | 26 | - |
| dc.contributor.affiliatedAuthor | Jeong Ho Choi | - |
| dc.contributor.affiliatedAuthor | Young-Kook Kim | - |
| dc.contributor.alternativeName | Singh | - |
| dc.contributor.alternativeName | Gajulapati | - |
| dc.contributor.alternativeName | Gajulapati | - |
| dc.contributor.alternativeName | 구자일 | - |
| dc.contributor.alternativeName | 박연화 | - |
| dc.contributor.alternativeName | 정화영 | - |
| dc.contributor.alternativeName | 이성윤 | - |
| dc.contributor.alternativeName | 최정호 | - |
| dc.contributor.alternativeName | 김영국 | - |
| dc.contributor.alternativeName | 이경 | - |
| dc.contributor.alternativeName | 허태해 | - |
| dc.contributor.alternativeName | 최용석 | - |
| dc.identifier.bibliographicCitation | Bioorganic & Medicinal Chemistry Letters, vol. 26, no. 4, pp. 1282-1286 | - |
| dc.identifier.doi | 10.1016/j.bmcl.2016.01.016 | - |
| dc.subject.keyword | gp130 | - |
| dc.subject.keyword | IL-6 antagonists | - |
| dc.subject.keyword | IL-6 signaling inhibitor | - |
| dc.subject.keyword | Oxazolidinone | - |
| dc.subject.keyword | Rheumatoid arthritis | - |
| dc.subject.keyword | STAT3 | - |
| dc.subject.local | gp130 | - |
| dc.subject.local | IL-6 antagonists | - |
| dc.subject.local | IL-6 signaling inhibitor | - |
| dc.subject.local | Oxazolidinone | - |
| dc.subject.local | Rheumatoid Arthritis | - |
| dc.subject.local | Rheumatoid arthritis | - |
| dc.subject.local | rheumatoid arthritis (RA) | - |
| dc.subject.local | rheumatoid arthritis | - |
| dc.subject.local | Signal transducer and activator of transcription 3 (STAT3) | - |
| dc.subject.local | Signal transducer and activator of transcription | - |
| dc.subject.local | Signal transducer and activator of transcription 3 (Stat3) | - |
| dc.subject.local | STAT 3 | - |
| dc.subject.local | STAT3 | - |
| dc.subject.local | Signal transducer and activator of transcription 3 | - |
| dc.subject.local | Stat3 | - |
| dc.subject.local | Signal transducer and activator of transcription factor 3 (STAT3) | - |
| dc.description.journalClass | Y | - |
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