GPR171 expression enhances proliferation and metastasis of lung cancer cells = GPR171 단백질의 폐암세포 증식 및 전이 조절 기전

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Title
GPR171 expression enhances proliferation and metastasis of lung cancer cells = GPR171 단백질의 폐암세포 증식 및 전이 조절 기전
Author(s)
So Hee Dho; Kwang-Pyo Lee; D Jeong; C J Kim; Kyung-Sook Chung; Ji Young Kim; Bum Chan Park; Sung Sup ParkSeon-Young KimKi Sun Kwon
Bibliographic Citation
Oncotarget, vol. 7, no. 7, pp. 7856-7865
Publication Year
2016
Abstract
G protein-coupled receptors (GPCRs) are among the most significant therapeutic targets and some of them promote the growth and metastasis of cancer. Here, we show that an increase in the levels of GPR171 is crucial for lung cancer tumor progression in vitro and in vivo. Immunostaining of clinical samples indicated that GPR171 was overexpressed in 46.8% of lung carcinoma tissues. Depletion of GPR171 with an anti-GPR171 antibody decreased proliferation of lung carcinoma cells and attenuated tumor progression in a mouse xenograft model. Knockdown of GPR171 also inhibited migration and invasion of the lung cancer cell lines. Notably, inhibition of GPR171 synergistically enhanced the tumoricidal activity of an epidermal growth factor receptor (EGFR) inhibitor in lung cancer cells. These results indicate that GPR171 blockade is a promising antineoplastic strategy and provide a preclinical rationale for combined inhibition of GPR171 and EGFR.
Keyword
EGFRGPCRGPR171Lung cancer
ISSN
1949-2553
Publisher
Impact Journals
DOI
http://dx.doi.org/10.18632/oncotarget.6856
Type
Article
Appears in Collections:
Division of Research on National Challenges > Aging Research Center > 1. Journal Articles
Division of Research on National Challenges > 1. Journal Articles
Korea Bioinformation Center > 1. Journal Articles
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