iRhoms : Its functions and essential roles

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Title
iRhoms : Its functions and essential roles
Author(s)
Min Young Lee; Ki Hoan Nam; K C Choi
Bibliographic Citation
Biomolecules & Therapeutics, vol. 24, no. 2, pp. 109-114
Publication Year
2016
Abstract
In Drosophila, rhomboid proteases are active cardinal regulators of epidermal growth factor receptor (EGFR) signaling pathway. iRhom1 and iRhom2, which are inactive homologs of rhomboid intramembrane serine proteases, are lacking essential catalytic residues. These are necessary for maturation and traffickingof tumor necrosis factor-alpha (TNF-α) converting enzyme (TACE) from endoplasmic reticulum (ER) to plasma membrane through Golgi, and associated with the fates of various ligands for EGFR. Recent studies have clarifiedthat the activation or downregulation of EGFR signaling pathways by alteration of iRhoms are connected to several human diseases including tylosis with esophageal cancer (TOC) which is the autosomal dominant syndrom, breast cancer, and Alzheimer’s disease. Thus, this review focuses on our understanding of iRhoms and the involved mechanisms in the cellular processes.
Keyword
EGFRIRhom1IRhom2TACETNF-α
ISSN
1976-9148
Publisher
South Korea
DOI
http://dx.doi.org/10.4062/biomolther.2015.149
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > Laboratory Animal Resource Center > 1. Journal Articles
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