DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ji Yong Yoon | - |
dc.contributor.author | Hyun Soo Cho | - |
dc.contributor.author | Jeong Ju Lee | - |
dc.contributor.author | Hyo Jung Lee | - |
dc.contributor.author | Soo Young Jun | - |
dc.contributor.author | Jae Hye Lee | - |
dc.contributor.author | Hyuk-Hwan Song | - |
dc.contributor.author | Sangho Choi | - |
dc.contributor.author | V Saloura | - |
dc.contributor.author | C G Park | - |
dc.contributor.author | C H Kim | - |
dc.contributor.author | Nam-Soon Kim | - |
dc.date.accessioned | 2017-04-19T10:18:52Z | - |
dc.date.available | 2017-04-19T10:18:52Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0899-1987 | - |
dc.identifier.uri | 10.1002/mc.22288 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/13184 | - |
dc.description.abstract | TRAIL (TNF-related apoptosis inducing ligand) is a promising anti-cancer drug target that selectively induces apoptosis in cancer cells. However, many cancer cells are resistant to TRAIL-induced apoptosis. Therefore, reversing TRAIL resistance is an important step for the development of effective TRAIL-based anti-cancer therapies. We previously reported that knockdown of the TOR signaling pathway regulator-like (TIPRL) protein caused TRAIL-induced apoptosis by activation of the MKK7-c-Jun N-terminal Kinase (JNK) pathway through disruption of the MKK7-TIPRL interaction. Here, we identified Taraxacum officinale F.H. Wigg (TO) as a novel TRAIL sensitizer from a set of 500 natural products using an ELISA system and validated its activity by GST pull-down analysis. Furthermore, combination treatment of Huh7 cells with TRAIL and TO resulted in TRAIL-induced apoptosis mediated through inhibition of the MKK7-TIPRL interaction and subsequent activation of MKK7-JNK phosphorylation. Interestingly, HPLC analysis identified chicoric acid as a major component of the TO extract, and combination treatment with chicoric acid and TRAIL induced TRAIL-induced cell apoptosis via JNK activation due to inhibition of the MKK7-TIPRL interaction. Our results suggest that TO plays an important role in TRAIL-induced apoptosis, and further functional studies are warranted to confirm the importance of TO as a novel TRAIL sensitizer for cancer therapy. | - |
dc.publisher | Wiley | - |
dc.title | Novel TRAIL sensitizer Taraxacum officinale F.H. Wigg enhances TRAIL-induced apoptosis in Huh7 cells | - |
dc.title.alternative | Novel TRAIL sensitizer Taraxacum officinale F.H. Wigg enhances TRAIL-induced apoptosis in Huh7 cells | - |
dc.type | Article | - |
dc.citation.title | Molecular Carcinogenesis | - |
dc.citation.number | 0 | - |
dc.citation.endPage | 396 | - |
dc.citation.startPage | 387 | - |
dc.citation.volume | 55 | - |
dc.contributor.affiliatedAuthor | Ji Yong Yoon | - |
dc.contributor.affiliatedAuthor | Hyun Soo Cho | - |
dc.contributor.affiliatedAuthor | Jeong Ju Lee | - |
dc.contributor.affiliatedAuthor | Hyo Jung Lee | - |
dc.contributor.affiliatedAuthor | Soo Young Jun | - |
dc.contributor.affiliatedAuthor | Jae Hye Lee | - |
dc.contributor.affiliatedAuthor | Hyuk-Hwan Song | - |
dc.contributor.affiliatedAuthor | Sangho Choi | - |
dc.contributor.affiliatedAuthor | Nam-Soon Kim | - |
dc.contributor.alternativeName | 윤지용 | - |
dc.contributor.alternativeName | 조현수 | - |
dc.contributor.alternativeName | 이정주 | - |
dc.contributor.alternativeName | 이효정 | - |
dc.contributor.alternativeName | 전수영 | - |
dc.contributor.alternativeName | 이재혜 | - |
dc.contributor.alternativeName | 송혁환 | - |
dc.contributor.alternativeName | 최상호 | - |
dc.contributor.alternativeName | Saloura | - |
dc.contributor.alternativeName | 박춘길 | - |
dc.contributor.alternativeName | 김철희 | - |
dc.contributor.alternativeName | 김남순 | - |
dc.identifier.bibliographicCitation | Molecular Carcinogenesis, vol. 55, pp. 387-396 | - |
dc.identifier.doi | 10.1002/mc.22288 | - |
dc.subject.keyword | Apoptosis | - |
dc.subject.keyword | HCC | - |
dc.subject.keyword | Taraxacum officinale F.H. Wigg | - |
dc.subject.keyword | TIPRL | - |
dc.subject.keyword | TRAIL resistance | - |
dc.subject.local | apoptosis | - |
dc.subject.local | Apoptosis | - |
dc.subject.local | HCC | - |
dc.subject.local | Taraxacum officinale F.H. Wigg | - |
dc.subject.local | TIPRL | - |
dc.subject.local | TRAIL resistance | - |
dc.description.journalClass | Y | - |
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