Novel TRAIL sensitizer Taraxacum officinale F.H. Wigg enhances TRAIL-induced apoptosis in Huh7 cells

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dc.contributor.authorJi Yong Yoon-
dc.contributor.authorHyun Soo Cho-
dc.contributor.authorJeong Ju Lee-
dc.contributor.authorHyo Jung Lee-
dc.contributor.authorSoo Young Jun-
dc.contributor.authorJae Hye Lee-
dc.contributor.authorHyuk-Hwan Song-
dc.contributor.authorSangho Choi-
dc.contributor.authorV Saloura-
dc.contributor.authorC G Park-
dc.contributor.authorC H Kim-
dc.contributor.authorNam-Soon Kim-
dc.date.accessioned2017-04-19T10:18:52Z-
dc.date.available2017-04-19T10:18:52Z-
dc.date.issued2016-
dc.identifier.issn0899-1987-
dc.identifier.uri10.1002/mc.22288ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/13184-
dc.description.abstractTRAIL (TNF-related apoptosis inducing ligand) is a promising anti-cancer drug target that selectively induces apoptosis in cancer cells. However, many cancer cells are resistant to TRAIL-induced apoptosis. Therefore, reversing TRAIL resistance is an important step for the development of effective TRAIL-based anti-cancer therapies. We previously reported that knockdown of the TOR signaling pathway regulator-like (TIPRL) protein caused TRAIL-induced apoptosis by activation of the MKK7-c-Jun N-terminal Kinase (JNK) pathway through disruption of the MKK7-TIPRL interaction. Here, we identified Taraxacum officinale F.H. Wigg (TO) as a novel TRAIL sensitizer from a set of 500 natural products using an ELISA system and validated its activity by GST pull-down analysis. Furthermore, combination treatment of Huh7 cells with TRAIL and TO resulted in TRAIL-induced apoptosis mediated through inhibition of the MKK7-TIPRL interaction and subsequent activation of MKK7-JNK phosphorylation. Interestingly, HPLC analysis identified chicoric acid as a major component of the TO extract, and combination treatment with chicoric acid and TRAIL induced TRAIL-induced cell apoptosis via JNK activation due to inhibition of the MKK7-TIPRL interaction. Our results suggest that TO plays an important role in TRAIL-induced apoptosis, and further functional studies are warranted to confirm the importance of TO as a novel TRAIL sensitizer for cancer therapy.-
dc.publisherWiley-
dc.titleNovel TRAIL sensitizer Taraxacum officinale F.H. Wigg enhances TRAIL-induced apoptosis in Huh7 cells-
dc.title.alternativeNovel TRAIL sensitizer Taraxacum officinale F.H. Wigg enhances TRAIL-induced apoptosis in Huh7 cells-
dc.typeArticle-
dc.citation.titleMolecular Carcinogenesis-
dc.citation.number0-
dc.citation.endPage396-
dc.citation.startPage387-
dc.citation.volume55-
dc.contributor.affiliatedAuthorJi Yong Yoon-
dc.contributor.affiliatedAuthorHyun Soo Cho-
dc.contributor.affiliatedAuthorJeong Ju Lee-
dc.contributor.affiliatedAuthorHyo Jung Lee-
dc.contributor.affiliatedAuthorSoo Young Jun-
dc.contributor.affiliatedAuthorJae Hye Lee-
dc.contributor.affiliatedAuthorHyuk-Hwan Song-
dc.contributor.affiliatedAuthorSangho Choi-
dc.contributor.affiliatedAuthorNam-Soon Kim-
dc.contributor.alternativeName윤지용-
dc.contributor.alternativeName조현수-
dc.contributor.alternativeName이정주-
dc.contributor.alternativeName이효정-
dc.contributor.alternativeName전수영-
dc.contributor.alternativeName이재혜-
dc.contributor.alternativeName송혁환-
dc.contributor.alternativeName최상호-
dc.contributor.alternativeNameSaloura-
dc.contributor.alternativeName박춘길-
dc.contributor.alternativeName김철희-
dc.contributor.alternativeName김남순-
dc.identifier.bibliographicCitationMolecular Carcinogenesis, vol. 55, pp. 387-396-
dc.identifier.doi10.1002/mc.22288-
dc.subject.keywordApoptosis-
dc.subject.keywordHCC-
dc.subject.keywordTaraxacum officinale F.H. Wigg-
dc.subject.keywordTIPRL-
dc.subject.keywordTRAIL resistance-
dc.subject.localapoptosis-
dc.subject.localApoptosis-
dc.subject.localHCC-
dc.subject.localTaraxacum officinale F.H. Wigg-
dc.subject.localTIPRL-
dc.subject.localTRAIL resistance-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Rare Disease Research Center > 1. Journal Articles
Division of Research on National Challenges > Stem Cell Convergenece Research Center > 1. Journal Articles
Ochang Branch Institute > Division of National Bio-Infrastructure > International Biological Material Research Center > 1. Journal Articles
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