DC Field | Value | Language |
---|---|---|
dc.contributor.author | A Shim | - |
dc.contributor.author | J H Song | - |
dc.contributor.author | B E Kwon | - |
dc.contributor.author | J J Lee | - |
dc.contributor.author | J H Ahn | - |
dc.contributor.author | Y J Kim | - |
dc.contributor.author | K J Rhee | - |
dc.contributor.author | S Y Chang | - |
dc.contributor.author | Y Cha | - |
dc.contributor.author | Y S Lee | - |
dc.contributor.author | M N Kwon | - |
dc.contributor.author | K S Park | - |
dc.contributor.author | Dong-Eun Kim | - |
dc.contributor.author | Sungchan Cho | - |
dc.contributor.author | H J Cho | - |
dc.contributor.author | H J Ko | - |
dc.date.accessioned | 2017-04-19T10:18:59Z | - |
dc.date.available | 2017-04-19T10:18:59Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | 10.1038/srep23110 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/13193 | - |
dc.description.abstract | Human rhinovirus (HRV) is the most common viral infectious agent in humans and is the predominant cause of the common cold. There is a need for appropriate vaccines or therapeutic agents to treat HRV infection. In this study, we investigated whether itraconazole (ICZ) can protect cells from HRV-induced cytotoxicity. Replication of HRV1B was reduced by ICZ treatment in the lungs of HRV1B- as compared to vehicle-treated mice. The numbers of immune cells, including granulocytes and monocytes, were reduced in bronchoalveolar lavage fluid (BALF) by ICZ administration after HRV1B infection, corresponding to decreased pro-inflammatory cytokine and chemokine levels in BALF. A histological analysis of lung tissue showed that ICZ suppressed inflammation caused by HRV1B infection. Interestingly, pretreatment of mice with ICZ in the form of a nasal spray had potent prophylactic antiviral activity. Cholesterol accumulation in the plasma membrane was observed upon HRV infection; ICZ blocked cholesterol trafficking to the plasma membrane, as well as resulted in its accumulation in subcellular compartments near the nucleus. These findings suggest that ICZ is a potential antiviral agent for the treatment of HRV infection, which can be adopted preventatively as well as therapeutically. | - |
dc.publisher | Springer-Nature Pub Group | - |
dc.title | Therapeutic and prophylactic activity of itraconazole against human rhinovirus infection in a murine model = 이트라코나졸의 감기바이러스 억제효능 | - |
dc.title.alternative | Therapeutic and prophylactic activity of itraconazole against human rhinovirus infection in a murine model | - |
dc.type | Article | - |
dc.citation.title | Scientific Reports | - |
dc.citation.number | 0 | - |
dc.citation.endPage | 23110 | - |
dc.citation.startPage | 23110 | - |
dc.citation.volume | 6 | - |
dc.contributor.affiliatedAuthor | Dong-Eun Kim | - |
dc.contributor.affiliatedAuthor | Sungchan Cho | - |
dc.contributor.alternativeName | 심애리 | - |
dc.contributor.alternativeName | 송재형 | - |
dc.contributor.alternativeName | 권보은 | - |
dc.contributor.alternativeName | 이정준 | - |
dc.contributor.alternativeName | 안재희 | - |
dc.contributor.alternativeName | 김연정 | - |
dc.contributor.alternativeName | 이기종 | - |
dc.contributor.alternativeName | 장선영 | - |
dc.contributor.alternativeName | 차영길 | - |
dc.contributor.alternativeName | 이용수 | - |
dc.contributor.alternativeName | 권미나 | - |
dc.contributor.alternativeName | 박귀성 | - |
dc.contributor.alternativeName | 김동은 | - |
dc.contributor.alternativeName | 조성찬 | - |
dc.contributor.alternativeName | 조현종 | - |
dc.contributor.alternativeName | 고현정 | - |
dc.identifier.bibliographicCitation | Scientific Reports, vol. 6, pp. 23110-23110 | - |
dc.identifier.doi | 10.1038/srep23110 | - |
dc.description.journalClass | Y | - |
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