Therapeutic and prophylactic activity of itraconazole against human rhinovirus infection in a murine model = 이트라코나졸의 감기바이러스 억제효능

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dc.contributor.authorA Shim-
dc.contributor.authorJ H Song-
dc.contributor.authorB E Kwon-
dc.contributor.authorJ J Lee-
dc.contributor.authorJ H Ahn-
dc.contributor.authorY J Kim-
dc.contributor.authorK J Rhee-
dc.contributor.authorS Y Chang-
dc.contributor.authorY Cha-
dc.contributor.authorY S Lee-
dc.contributor.authorM N Kwon-
dc.contributor.authorK S Park-
dc.contributor.authorDong-Eun Kim-
dc.contributor.authorSungchan Cho-
dc.contributor.authorH J Cho-
dc.contributor.authorH J Ko-
dc.date.accessioned2017-04-19T10:18:59Z-
dc.date.available2017-04-19T10:18:59Z-
dc.date.issued2016-
dc.identifier.issn2045-2322-
dc.identifier.uri10.1038/srep23110ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/13193-
dc.description.abstractHuman rhinovirus (HRV) is the most common viral infectious agent in humans and is the predominant cause of the common cold. There is a need for appropriate vaccines or therapeutic agents to treat HRV infection. In this study, we investigated whether itraconazole (ICZ) can protect cells from HRV-induced cytotoxicity. Replication of HRV1B was reduced by ICZ treatment in the lungs of HRV1B- as compared to vehicle-treated mice. The numbers of immune cells, including granulocytes and monocytes, were reduced in bronchoalveolar lavage fluid (BALF) by ICZ administration after HRV1B infection, corresponding to decreased pro-inflammatory cytokine and chemokine levels in BALF. A histological analysis of lung tissue showed that ICZ suppressed inflammation caused by HRV1B infection. Interestingly, pretreatment of mice with ICZ in the form of a nasal spray had potent prophylactic antiviral activity. Cholesterol accumulation in the plasma membrane was observed upon HRV infection; ICZ blocked cholesterol trafficking to the plasma membrane, as well as resulted in its accumulation in subcellular compartments near the nucleus. These findings suggest that ICZ is a potential antiviral agent for the treatment of HRV infection, which can be adopted preventatively as well as therapeutically.-
dc.publisherSpringer-Nature Pub Group-
dc.titleTherapeutic and prophylactic activity of itraconazole against human rhinovirus infection in a murine model = 이트라코나졸의 감기바이러스 억제효능-
dc.title.alternativeTherapeutic and prophylactic activity of itraconazole against human rhinovirus infection in a murine model-
dc.typeArticle-
dc.citation.titleScientific Reports-
dc.citation.number0-
dc.citation.endPage23110-
dc.citation.startPage23110-
dc.citation.volume6-
dc.contributor.affiliatedAuthorDong-Eun Kim-
dc.contributor.affiliatedAuthorSungchan Cho-
dc.contributor.alternativeName심애리-
dc.contributor.alternativeName송재형-
dc.contributor.alternativeName권보은-
dc.contributor.alternativeName이정준-
dc.contributor.alternativeName안재희-
dc.contributor.alternativeName김연정-
dc.contributor.alternativeName이기종-
dc.contributor.alternativeName장선영-
dc.contributor.alternativeName차영길-
dc.contributor.alternativeName이용수-
dc.contributor.alternativeName권미나-
dc.contributor.alternativeName박귀성-
dc.contributor.alternativeName김동은-
dc.contributor.alternativeName조성찬-
dc.contributor.alternativeName조현종-
dc.contributor.alternativeName고현정-
dc.identifier.bibliographicCitationScientific Reports, vol. 6, pp. 23110-23110-
dc.identifier.doi10.1038/srep23110-
dc.description.journalClassY-
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Ochang Branch Institute > Nucleic Acid Therapeutics Research Center > 1. Journal Articles
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