New cyclic lipopeptides of the iturin class produced by saltern-derived Bacillus sp. KCB14S006 = 염전유래 Bacillus sp. KCB14S006로부터 분리한 신규 cyclic lipopeptides

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dc.contributor.authorSangkeun Son-
dc.contributor.authorSung-Kyun Ko-
dc.contributor.authorMina Jang-
dc.contributor.authorJong Won Kim-
dc.contributor.authorGil Soo Kim-
dc.contributor.authorJae Kyoung Lee-
dc.contributor.authorEun Soo Jeon-
dc.contributor.authorY Futamura-
dc.contributor.authorIn Ja Ryoo-
dc.contributor.authorJung-Sook Lee-
dc.contributor.authorH Oh-
dc.contributor.authorYoung-Soo Hong-
dc.contributor.authorBo Yeon Kim-
dc.contributor.authorS Takahashi-
dc.contributor.authorH Osada-
dc.contributor.authorJae-Hyuk Jang-
dc.contributor.authorJong Seog Ahn-
dc.date.accessioned2017-04-19T10:19:52Z-
dc.date.available2017-04-19T10:19:52Z-
dc.date.issued2016-
dc.identifier.issn1660-3397-
dc.identifier.uri10.3390/md14040072ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/13217-
dc.description.abstractSalterns, one of the most extreme natural hypersaline environments, are a rich source of halophilic and halotolerant microorganisms, but they remain largely underexplored ecological niches in the discovery of bioactive secondary metabolites. In continued efforts to investigate the metabolic potential of microbial populations from chemically underexplored sites, three new lipopeptides named iturin F1, iturin F2 and iturin A9 (1-3), along with iturin A8 (4), were isolated from Bacillus sp. KCB14S006 derived from a saltern. The structures of the isolated compounds were established by 1D-, 2D-NMR and HR-ESIMS, and their absolute configurations were determined by applying advanced Marfey's method and CD spectroscopy. All isolates exhibited significant antifungal activities against various pathogenic fungi and moderate cytotoxic activities toward HeLa and srcts-NRK cell lines. Moreover, in an in vitro enzymatic assay, compound 4 showed a significant inhibitory activity against indoleamine 2,3-dioxygenase.-
dc.publisherMDPI-
dc.titleNew cyclic lipopeptides of the iturin class produced by saltern-derived Bacillus sp. KCB14S006 = 염전유래 Bacillus sp. KCB14S006로부터 분리한 신규 cyclic lipopeptides-
dc.title.alternativeNew cyclic lipopeptides of the iturin class produced by saltern-derived Bacillus sp. KCB14S006-
dc.typeArticle-
dc.citation.titleMarine Drugs-
dc.citation.number4-
dc.citation.endPage72-
dc.citation.startPage72-
dc.citation.volume14-
dc.contributor.affiliatedAuthorSangkeun Son-
dc.contributor.affiliatedAuthorSung-Kyun Ko-
dc.contributor.affiliatedAuthorMina Jang-
dc.contributor.affiliatedAuthorJong Won Kim-
dc.contributor.affiliatedAuthorGil Soo Kim-
dc.contributor.affiliatedAuthorJae Kyoung Lee-
dc.contributor.affiliatedAuthorEun Soo Jeon-
dc.contributor.affiliatedAuthorIn Ja Ryoo-
dc.contributor.affiliatedAuthorJung-Sook Lee-
dc.contributor.affiliatedAuthorYoung-Soo Hong-
dc.contributor.affiliatedAuthorBo Yeon Kim-
dc.contributor.affiliatedAuthorJae-Hyuk Jang-
dc.contributor.affiliatedAuthorJong Seog Ahn-
dc.contributor.alternativeName손상근-
dc.contributor.alternativeName고성균-
dc.contributor.alternativeName장민아-
dc.contributor.alternativeName김종원-
dc.contributor.alternativeName김길수-
dc.contributor.alternativeName이재경-
dc.contributor.alternativeName전은수-
dc.contributor.alternativeNameFutamura-
dc.contributor.alternativeName류인자-
dc.contributor.alternativeName이정숙-
dc.contributor.alternativeName오현철-
dc.contributor.alternativeName홍영수-
dc.contributor.alternativeName김보연-
dc.contributor.alternativeNameTakahashi-
dc.contributor.alternativeNameOsada-
dc.contributor.alternativeName장재혁-
dc.contributor.alternativeName안종석-
dc.identifier.bibliographicCitationMarine Drugs, vol. 14, no. 4, pp. 72-72-
dc.identifier.doi10.3390/md14040072-
dc.subject.keywordAntifungal-
dc.subject.keywordCytotoxic-
dc.subject.keywordIndoleamine-2,3-dioxygenase-
dc.subject.keywordIturins-
dc.subject.keywordSaltern-derived bacteria-
dc.subject.localantifungal-
dc.subject.localAntifungal-
dc.subject.localAnti-fungal-
dc.subject.localCytotoxic-
dc.subject.localcytotoxic-
dc.subject.localIndoleamine 2,3-dioxygenase (IDO)-
dc.subject.localindoleamine 2,3-dioxygenase-
dc.subject.localIndoleamine-2,3-dioxygenase-
dc.subject.localindoleamine 2,3-dioxygenase (IDO)-
dc.subject.localIturins-
dc.subject.localSaltern-derived bacteria-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
Jeonbuk Branch Institute > Biological Resource Center > 1. Journal Articles
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