DC Field | Value | Language |
---|---|---|
dc.contributor.author | Seongsoo Lee | - |
dc.contributor.author | Kyu-Sun Lee | - |
dc.contributor.author | S Huh | - |
dc.contributor.author | S Liu | - |
dc.contributor.author | D Y Lee | - |
dc.contributor.author | Seung Hyun Hong | - |
dc.contributor.author | Kweon Yu | - |
dc.contributor.author | B Lu | - |
dc.date.accessioned | 2017-04-19T10:20:17Z | - |
dc.date.available | 2017-04-19T10:20:17Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1534-5807 | - |
dc.identifier.uri | 10.1016/j.devcel.2016.03.023 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/13228 | - |
dc.description.abstract | Mitochondria play central roles in buffering intracellular Ca2+ transients. While basal mitochondrial Ca2+ (Ca2+ mito) is needed to maintain organellar physiology, Ca2+ mito overload can lead to cell death. How Ca2+ mito homeostasis is regulated is not well understood. Here we show that Miro, a known component of the mitochondrial transport machinery, regulates Drosophila neural stem cell (NSC) development through Ca2+ mito homeostasis control, independent of its role in mitochondrial transport. Miro interacts with Ca2+ transporters at the ER-mitochondria contact site (ERMCS). Its inactivation causes Ca2+ mito depletion and metabolic impairment, whereas its overexpression results in Ca2+ mito overload, mitochondrial morphology change, and apoptotic response. Both conditions impaired NSC lineage progression. Ca2+ mito homeostasis is influenced by Polo-mediated phosphorylation of a conserved residue in Miro, which positively regulates Miro localization to, and the integrity of, ERMCS. Our results elucidate a regulatory mechanism underlying Ca2+ mito homeostasis and how its dysregulation may affect NSC metabolism/development and contribute to disease. | - |
dc.publisher | Elsevier-Cell Press | - |
dc.title | Polo kinase phosphorylates Miro to control ER-mitochondria contact sites and mitochondrial Ca2+ homeostasis in neural stem cell development | - |
dc.title.alternative | Polo kinase phosphorylates Miro to control ER-mitochondria contact sites and mitochondrial Ca2+ homeostasis in neural stem cell development | - |
dc.type | Article | - |
dc.citation.title | Developmental Cell | - |
dc.citation.number | 2 | - |
dc.citation.endPage | 189 | - |
dc.citation.startPage | 174 | - |
dc.citation.volume | 37 | - |
dc.contributor.affiliatedAuthor | Seongsoo Lee | - |
dc.contributor.affiliatedAuthor | Kyu-Sun Lee | - |
dc.contributor.affiliatedAuthor | Seung Hyun Hong | - |
dc.contributor.affiliatedAuthor | Kweon Yu | - |
dc.contributor.alternativeName | 이성수 | - |
dc.contributor.alternativeName | 이규선 | - |
dc.contributor.alternativeName | 허성운 | - |
dc.contributor.alternativeName | Liu | - |
dc.contributor.alternativeName | 이도연 | - |
dc.contributor.alternativeName | 홍승현 | - |
dc.contributor.alternativeName | 유권 | - |
dc.contributor.alternativeName | Lu | - |
dc.identifier.bibliographicCitation | Developmental Cell, vol. 37, no. 2, pp. 174-189 | - |
dc.identifier.doi | 10.1016/j.devcel.2016.03.023 | - |
dc.description.journalClass | Y | - |
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