DC Field | Value | Language |
---|---|---|
dc.contributor.author | S Kim | - |
dc.contributor.author | Jin Hoi Song | - |
dc.contributor.author | Seok Ho Kim | - |
dc.contributor.author | P Qu | - |
dc.contributor.author | B K Martin | - |
dc.contributor.author | W S Sehareen | - |
dc.contributor.author | D C Haines | - |
dc.contributor.author | P C Lin | - |
dc.contributor.author | S K Sharan | - |
dc.contributor.author | S Chang | - |
dc.date.accessioned | 2017-04-19T10:20:49Z | - |
dc.date.available | 2017-04-19T10:20:49Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1949-2553 | - |
dc.identifier.uri | 10.18632/oncotarget.7150 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/13238 | - |
dc.description.abstract | The oncogenic role of microRNA-155 (miR-155) in leukemia is well established but its role in other cancers, especially breast cancer, is gradually emerging. In this study we examined the effect of mir-155 loss in a well-characterized spontaneous breast cancer mouse model where Brca1 and Trp53 are deleted by K14-Cre. miR-155 is known to be up-regulated in BRCA1-deficient tumors. Surprisingly, complete loss of miR-155 (miR-155ko/ko) did not alter the tumor free survival of the mutant mice. However, we found increased infiltration of myeloid derived suppressor cells (MDSCs) in miR-155 deficient tumors. In addition, cytokine/chemokine array analysis revealed altered level of cytokines that are implicated in the recruitment of MDSCs. Mechanistically, we identified C/EBP-β, a known miR-155 target, to regulate the expression of these cytokines in the miR-155-deficient cells. Furthermore, using an allograft model, we showed that inhibition of miR-155 in cancer cells suppressed in vivo growth, which was restored by the loss of miR-155 in the microenvironment. Taken together, we have uncovered a novel tumor suppressive function of miR-155 in the tumor microenvironment, which is also dependent on miR-155 expression in the tumor cells. Because of the oncogenic as well as tumor suppressive roles of miR-155, our findings warrant caution against a systemic inhibition of miR-155 for anticancer therapy. | - |
dc.publisher | Impact Journals | ko |
dc.title | Loss of oncogenic miR-155 in tumor cells promotes tumor growth by enhancing C/EBP-β-mediated MDSC infiltration | - |
dc.title.alternative | Loss of oncogenic miR-155 in tumor cells promotes tumor growth by enhancing C/EBP-β-mediated MDSC infiltration | - |
dc.type | Article | - |
dc.citation.title | Oncotarget | - |
dc.citation.number | 10 | - |
dc.citation.endPage | 11112 | - |
dc.citation.startPage | 11094 | - |
dc.citation.volume | 7 | - |
dc.contributor.affiliatedAuthor | Jin Hoi Song | - |
dc.contributor.affiliatedAuthor | Seok Ho Kim | - |
dc.contributor.alternativeName | 김시내 | - |
dc.contributor.alternativeName | 송진회 | - |
dc.contributor.alternativeName | 김석호 | - |
dc.contributor.alternativeName | Qu | - |
dc.contributor.alternativeName | Martin | - |
dc.contributor.alternativeName | Sehareen | - |
dc.contributor.alternativeName | Haines | - |
dc.contributor.alternativeName | Lin | - |
dc.contributor.alternativeName | Sharan | - |
dc.contributor.alternativeName | 장수환 | - |
dc.identifier.bibliographicCitation | Oncotarget, vol. 7, no. 10, pp. 11094-11112 | - |
dc.identifier.doi | 10.18632/oncotarget.7150 | - |
dc.subject.keyword | Breast cancer | - |
dc.subject.keyword | C/EBP-beta | - |
dc.subject.keyword | Cytokine | - |
dc.subject.keyword | MDSC | - |
dc.subject.keyword | miR-155 | - |
dc.subject.local | breast cancer | - |
dc.subject.local | Breast cancer | - |
dc.subject.local | Breast Cancer | - |
dc.subject.local | C/EBPβ | - |
dc.subject.local | C/EBP-beta | - |
dc.subject.local | cytokine | - |
dc.subject.local | Cytokines | - |
dc.subject.local | Cytokine | - |
dc.subject.local | MDSC | - |
dc.subject.local | miR-155 | - |
dc.description.journalClass | N | - |
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