Specific expression and methylation of SLIT1, SLIT2, SLIT3, and miR-218 in gastric cancer subtypes

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dc.contributor.authorMirang Kim-
dc.contributor.authorJong-Hwan Kim-
dc.contributor.authorSu-Jin Baek-
dc.contributor.authorSeon-Young Kim-
dc.contributor.authorYong Sung Kim-
dc.date.accessioned2017-04-19T10:20:49Z-
dc.date.available2017-04-19T10:20:49Z-
dc.date.issued2016-
dc.identifier.issn10196439-
dc.identifier.uri10.3892/ijo.2016.3473ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/13241-
dc.description.abstractSLIT has been suggested as a key regulator of cancer development and a promising therapeutic target for cancer treatment. Herein, we analyzed expression and methylation of SLIT1/SLIT2/SLIT3 in 11 gastric cancer cell lines, 96 paired gastric tumors and adjacent normal gastric tissues, and 250 gastric cancers provided by The Cancer Genome Atlas. Methylation of SLIT1/SLIT2/SLIT3 was found both in early gastric cancers, and in advanced gastric cancers. Even normal gastric tissue showed increased methylation of SLIT1 and SLIT3 that correlated with patient age. Furthermore, epigenetic inactivation of SLIT occurred in a gastric cancer subtype-dependent manner. SLIT2 and SLIT3 expression was reduced in Epstein-Barr virus-positive and microsatellite instability subtypes, but increased in the genomically stable subtype. Expression of miR-218 correlated negatively with methylation of SLIT2 or SLIT3. These findings suggest that a molecular subtype-specific therapeutic strategy is needed for targeting SLITs and miR-218 in treatment of gastric cancer.-
dc.publisherSpandidos Publ Ltd-
dc.titleSpecific expression and methylation of SLIT1, SLIT2, SLIT3, and miR-218 in gastric cancer subtypes-
dc.title.alternativeSpecific expression and methylation of SLIT1, SLIT2, SLIT3, and miR-218 in gastric cancer subtypes-
dc.typeArticle-
dc.citation.titleInternational Journal of Oncology-
dc.citation.number0-
dc.citation.endPage2507-
dc.citation.startPage2497-
dc.citation.volume48-
dc.contributor.affiliatedAuthorMirang Kim-
dc.contributor.affiliatedAuthorSeon-Young Kim-
dc.contributor.affiliatedAuthorYong Sung Kim-
dc.contributor.alternativeName김미랑-
dc.contributor.alternativeName김종환-
dc.contributor.alternativeName백수진-
dc.contributor.alternativeName김선영-
dc.contributor.alternativeName김용성-
dc.identifier.bibliographicCitationInternational Journal of Oncology, vol. 48, pp. 2497-2507-
dc.identifier.doi10.3892/ijo.2016.3473-
dc.subject.keywordGastric cancer-
dc.subject.keywordMethylation-
dc.subject.keywordMIR-218-
dc.subject.keywordSLIT1-
dc.subject.keywordSLIT2-
dc.subject.keywordSLIT3-
dc.subject.localGastric cancer-
dc.subject.localMethylation-
dc.subject.localMIR-218-
dc.subject.localSLIT1-
dc.subject.localSLIT2-
dc.subject.localSLIT3-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Personalized Genomic Medicine Research Center > 1. Journal Articles
Korea Bioinformation Center > 1. Journal Articles
Division of Biomedical Research > Genome Editing Research Center > 1. Journal Articles
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