Extract of Ettlia sp. YC001 exerts photoprotective effects against UVB irradiation in normal human dermal fibroblasts

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Title
Extract of Ettlia sp. YC001 exerts photoprotective effects against UVB irradiation in normal human dermal fibroblasts
Author(s)
J J Lee; S An; K B Kim; Jina Heo; Dae Hyun ChoHee-Mock OhHee-Sik Kim; S Bae
Bibliographic Citation
Journal of Microbiology and Biotechnology, vol. 26, no. 4, pp. 775-783
Publication Year
2016
Abstract
The identification of novel reagents that exert a biological ultraviolet (UV)-protective effect in skin cells represents an important strategy for preventing UV-induced skin aging. To this end, we investigated the potential protective effects of Ettlia sp. YC001 extracts against UV-induced cellular damage in normal human dermal fibroblasts (NHDFs). We generated four different extracts from Ettlia sp. YC001, and found that they exhibit low cytotoxicity in NHDFs. The ethyl acetate extract of Ettlia sp. YC001 markedly decreased UVB-induced cytotoxicity. Additionally, the ethyl acetate extract significantly inhibited the production of hydrogen peroxide-induced reactive oxygen species. Moreover, it inhibited UVB-induced thymine dimers, as confirmed by luciferase assay and thymine dimer dot-blot assay. Thus, the study findings suggest Ettlia sp. YC001 extract as a novel photoprotective reagent on UVB-induced cell dysfunctions in NHDFs.
Keyword
Dermal fibroblastsEttlia sp. YC001PhotoagingPhotoprotectionSkinUltraviolet B
ISSN
1017-7825
Publisher
South Korea
DOI
http://dx.doi.org/10.4014/jmb.1509.09067
Type
Article
Appears in Collections:
Division of Biomaterials Research > Cell Factory Research Center > 1. Journal Articles
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